Cyclotron 99mTc Production and Quality Control for Medical Applications

被引：0

作者：

Al Rayyes, A. H. ^{[1
]}

Assaad, T. ^{[1
]}

Ailouti, Y. ^{[1
]}

机构：

[1] Atom Energy Commiss Syria, Radioisotopes Dept, Cyclotron Div, POB 6091, Damascus, Syria

来源：

RADIOCHEMISTRY | 2019年 / 61卷 / 01期

关键词：

technetium-99m; cyclotron; radioisotope production; ion-exchange chromatography; solid targets; EXCITATION-FUNCTIONS; MO-100;

D O I：

10.1134/S1066362219010120

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new production method of 99mTc using a high-current solid target was tested. The separation and purification setup was developed to produce high quantity and high specific activity of 99mTcO4 -suitable for labeling various ligands for nuclear medicine imaging. A semiautomated target dissolution and separation system has been developed for 99mTcO4 -production. The separation is based on a chromatographic column system. The chemical and radiochemical purity was found to be in accordance with the US and European Pharmacopoeia specifications. 99% of activity in the final product belonged to 99mTc. Less than 1% of the 99mTc activity was not incorporated in the target product with MDP kits. Biodistribution data for the labeled MDP kits show that the quality of the produced 99mTc-pertechnetate is identical to that of the pertechnetate from 99Mo/ 99mTc generators. The application of 99mTc-ethylenedicysteine in human proves the good quality of the produced Na99mTcO4.

引用

页码：81 / 85

页数：5

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