Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum

被引：32

作者：

Devi, Asshaima Paramita ^{[1
,2
]}

Thuc-Huy Duong ^{[3
]}

Ferron, Solenn ^{[4
]}

Beniddir, Mehdi A. ^{[5
]}

Minh-Hiep Dinh ^{[6
]}

Van-Kieu Nguyen ^{[7
,8
]}

Nguyen-Kim-Tuyen Pham ^{[9
]}

Dinh-Hung Mac ^{[10
]}

Boustie, Joel ^{[4
]}

Chavasiri, Warinthorn ^{[1
]}

Le Pogam, Pierre ^{[5
]}

机构：

[1] Chulalongkorn Univ, Fac Sci, Ctr Excellence Nat Prod Chem, Dept Chem, Bangkok, Thailand

[2] Chulalongkorn Univ, Fac Sci, Program Biotechnol, Bangkok, Thailand

[3] Ho Chi Minh City Univ Educ, Dept Chem, Ho Chi Minh City, Vietnam

[4] Univ Rennes, ISCR Inst Sci Chim Rennes, CNRS, UMR 6226, Rennes, France

[5] Univ Paris Sud, Univ Paris Saclay, CNRS, Equipe Pharmacognosie Chim Subst Nat,BioCIS, 5 Rue Jean Baptiste Clement, F-92290 Chatenay Malabry, France

[6] Management Board Ho Chi Minh City Agr Hitech Pk, Ho Chi Minh City, Vietnam

[7] Duy Tan Univ, Inst Fundamental & Appl Sci, Ho Chi Minh City, Vietnam

[8] Duy Tan Univ, Fac Nat Sci, Da Nang, Vietnam

[9] Sai Gon Univ, Fac Environm Sci, Ho Chi Minh City, Vietnam

[10] VNU Univ Sci, Dept Organ Chem, Hanoi, Vietnam

来源：

PLANTA MEDICA | 2020年 / 86卷 / 16期

关键词：

depsidones; Diphenylethers; alpha-glucosidase; Lichens; Polyphenolics; Parmotrema dilatatum; FUNGUS; ETHERS; IDENTIFICATION; METABOLITES; DIVERSITY; H-1;

D O I：

10.1055/a-1203-0623

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new depsidones, parmosidones F - G (1 - 2), and 8 '-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A - C (4 - 6), together with 2 known congeners were isolated from the whole thalli ofParmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive spectroscopic analyses and comparison with literature data. The isolated polyphenolics were assayed for their alpha-glucosidase inhibitory activities. Newly reported benzylated depsidones1and2in particular inhibited alpha-glucosidase with IC(50)values of 2.2 and 4.3 mu M, respectively, and are thus more potent than the positive control, acarbose.

引用

页码：1216 / 1224

页数：9

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