Leptin in acute coronary syndromes: Has the time come for its use in risk stratification?

被引：1
作者：
Amasyali, Basri
Kose, Sedat
Kursaklioglu, Hurkan
Kilic, Ayhan
Isik, Ersoy
机构：
[1] Gulhane Military Medical School, Department of Cardiology
[2] Gulhane Military Medical School, Department of Pediatric Cardiology
来源：
INTERNATIONAL JOURNAL OF CARDIOLOGY | 2008年 / 130卷 / 02期
关键词：
Leptin; Acute coronary syndromes; Thrombosis;
D O I：
10.1016/j.ijcard.2007.07.007
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Leptin, a recently discovered obesity gene product, is primarily involved in the regulation of food intake and energy expenditure. Recent observations suggest that leptin has a much broader biological role other than regulation of body weight and energy metabolism. It has been shown that leptin increases sympathetic nerve activity, stimulates generation of reactive oxygen species, induces platelet aggregation and promotes arterial thrombosis, and is an independent risk factor for coronary heart disease. In this paper, we discussed the role of leptin in the pathogenesis of acute coronary syndromes and its usefulness as a biomarker for risk stratification in acute coronary syndromes. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：264 / 265
页数：2
相关论文
共 15 条
[1]   Admission plasma leptin level strongly correlates with the success of thrombolytic therapy in patients with acute myocardial infarction [J].
Amasyali, Basri ;
Aytemir, Kudret ;
Kose, Sedat ;
Kilic, Ayhan ;
Abali, Gulcan ;
Iyisoy, Atila ;
Kursaklioglu, Hurkan ;
Turan, Mustafa ;
Bingol, Necati ;
Isik, Ersoy ;
Demirtas, Ertan .
ANGIOLOGY, 2006, 57 (06) :671-680
[2]   Inflammation and acute coronary syndromes [J].
Biasucci, LM ;
Liuzzo, G ;
Angiolillo, DJ ;
Sperti, G ;
Maseri, A .
HERZ, 2000, 25 (02) :108-112
[3]   Leptin induces oxidative stress in human endothelial cells [J].
Bouloumié, A ;
Marumo, T ;
Lafontan, M ;
Busse, R .
FASEB JOURNAL, 1999, 13 (10) :1231-1238
[4]   Plasma plasminogen activator inhibitor-I is associated with plasma leptin irrespective of body mass index, body fat mass, and plasma insulin and metabolic parameters in premenopausal women [J].
De Mitrio, V ;
De Pergola, G ;
Vettor, R ;
Marino, R ;
Sciaraffia, M ;
Pagano, C ;
Scaraggi, FA ;
Di Lorenzo, L ;
Giorgino, R .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1999, 48 (08) :960-964
[5]   Insulin resistance in moderate chronic heart failure is related to hyperleptinaemia, but not to norepinephrine or TNF-alpha [J].
Doehner, W ;
Rauchhaus, M ;
Godsland, IF ;
Egerer, K ;
Niebauer, J ;
Sharma, R ;
Cicoira, M ;
Florea, VG ;
Coats, AJS ;
Anker, SD .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2002, 83 (01) :73-81
[6]   Association of plasma leptin levels and complexity of the culprit lesion in patients with unstable angina [J].
Dubey, Laxman ;
Zeng, Hesong ;
Hashmi, Satwat ;
Wang Hongjie ;
Tao, He .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2008, 126 (02) :183-189
[7]   Interleukin 1 alpha increases serum leptin concentrations in humans [J].
Janik, JE ;
Curti, BD ;
Considine, RV ;
Rager, HC ;
Powers, GC ;
Alvord, WG ;
Smith, JW ;
Gause, BL ;
Kopp, WC .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (09) :3084-3086
[8]   Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity [J].
Konstantinides, S ;
Schäfer, K ;
Koschnick, S ;
Loskutoff, DJ .
JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (10) :1533-1540
[9]   Leptin induces tissue factor expression in human peripheral blood mononuclear cells: a possible link between obesity and cardiovascular risk? [J].
Napoleone, E. ;
Di Santo, A. ;
Amore, C. ;
Baccante, G. ;
Di Febbo, C. ;
Porreca, E. ;
de Gaetano, G. ;
Donati, M. B. ;
Lorenzet, R. .
JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2007, 5 (07) :1462-1468
[10]   Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia [J].
Sarraf, P ;
Frederich, RC ;
Turner, EM ;
Ma, G ;
Jaskowiak, NT ;
Rivet, DJ ;
Flier, JS ;
Lowell, BB ;
Fraker, DL ;
Alexander, HR .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 185 (01) :171-175
12