A Step toward Standardization: Results of two National Surveys of Best Practices in Donation after Circulatory Death Liver Recovery and Recommendations from The American Society of Transplant Surgeons and Association of Organ Procurement Organizations

被引:17
作者
Hobeika, Mark J. [1 ]
Glazner, Robert [2 ]
Foley, David P. [3 ]
Hanish, Steven [4 ]
Loss, George [5 ]
Quintini, Cristiano [6 ]
Eidbo, Elling [7 ]
Zollinger, Charles [8 ]
Ruterbories, Jay [9 ]
Lebovitz, Daniel J. [10 ,11 ]
Axelrod, David [12 ]
机构
[1] Houston Methodist Hosp, Weill Cornell Med Coll, Dept Surg, 6550 Fannin St,Smith Tower,Suite 1661, Houston, TX 77030 USA
[2] Donor Network Arizona, Phoenix, AZ USA
[3] Univ Wisconsin, Dept Surg, Sch Med & Publ Hlth, Madison, WI USA
[4] Univ Texas Southwestern Med Ctr Dallas, Dept Surg, Dallas, TX USA
[5] Oschner Clin Fdn, Dept Surg, New Orleans, LA USA
[6] Cleveland Clin, Liver Transplantat Program, Cleveland, OH 44106 USA
[7] Assoc Organ Procurement Org, Vienna, VA USA
[8] Donor Connect, Salt Lake City, UT USA
[9] Donor Alliance, Denver, CO USA
[10] Lifebanc, Cleveland, OH USA
[11] Akron Childrens Hosp, Akron, OH 44308 USA
[12] Univ Iowa, Dept Surg, Carver Coll Med, Iowa City, IA 52242 USA
关键词
CARDIAC DEATH; UNITED NETWORK; DONORS; POLICY; PREDICTORS; WITHDRAWAL; HEART; TIME;
D O I
10.1111/ctr.14035
中图分类号
R61 [外科手术学];
学科分类号
摘要
Donation after circulatory death (DCD) liver allografts remain underutilized. Inconsistent processes for DCD procurement may contribute to allograft discard. Optimal surgical and organ procurement organization (OPO) practices for DCD liver recovery should be developed and adopted. DCD practice surveys were distributed to transplant surgeons and OPO leadership. DCD liver recovery best practices were assembled based on survey data, literature review, and subject-matter expert consensus opinion. Data were obtained from transplant surgeons (n = 188) and OPO leadership (n = 48 OPOs). Surgeons preferred attending physician presence at recovery (72.4%); while only 27.7% of OPOs require this. Pre-withdrawal communication huddle (Surgeons: 88.7%; OPOs: 93.8%) and administration of pre-withdrawal heparin (Surgeons: 90.6%; OPOs: 84.8%) are widely accepted. Surgical preference for withdrawal of support is in the operating room (89.3%); OPO practice varies dependent upon hospital and family requirements. Functional donor warm ischemic time (fDWIT) start time is variable, while fDWIT end time is agreed upon as initiation of aortic flush by surgeons (81%) and OPOs (81%). DCD liver recovery practices including mandatory communication huddle, pre-withdrawal heparin administration, and clearly defined start and end of fDWIT should be implemented nationally. Creating a set of best practices for DCD recovery guidelines is necessary for improving DCD liver utilization.
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页数:7
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共 28 条
[1]   Liver transplantation from controlled non-heartbeating donors: An increased incidence of biliary complications [J].
Abt, P ;
Crawford, M ;
Desai, N ;
Markmann, J ;
Olthoff, K ;
Shaked, A .
TRANSPLANTATION, 2003, 75 (10) :1659-1663
[2]   Report of a national conference on donation after cardiac death [J].
Bernat, JL ;
D'Alessandro, AM ;
Port, FK ;
Bleck, TP ;
Heard, SO ;
Medina, J ;
Rosenbaum, SH ;
DeVita, MA ;
Gaston, RS ;
Merion, RM ;
Barr, ML ;
Marks, WH ;
Nathan, H ;
O'Connor, K ;
Rudow, DL ;
Leichtman, AB ;
Schwab, P ;
Ascher, NL ;
Metzger, RA ;
Mc Bride, V ;
Graham, W ;
Wagner, D ;
Warren, J ;
Delmonico, FL .
AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (02) :281-291
[3]   Safety and Outcomes in 100 Consecutive Donation After Circulatory Death Liver Transplants Using a Protocol That Includes Thrombolytic Therapy [J].
Bohorquez, H. ;
Seal, J. B. ;
Cohen, A. J. ;
Kressel, A. ;
Bugeaud, E. ;
Bruce, D. S. ;
Carmody, I. C. ;
Reichman, T. W. ;
Battula, N. ;
Alsaggaf, M. ;
Therapondos, G. ;
Bzowej, N. ;
Tyson, G. ;
Joshi, S. ;
Nicolau-Raducu, R. ;
Girgrah, N. ;
Loss, G. E. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 (08) :2155-2164
[4]   Donation After Circulatory Death for Liver Transplantation: A Meta-Analysis on the Location of Life Support Withdrawal Affecting Outcomes [J].
Cao, Yiming ;
Shahrestani, Sara ;
Chew, Hong Chee ;
Crawford, Michael ;
Macdonald, Peter Simon ;
Laurence, Jerome ;
Hawthorne, Wayne John ;
Dhital, Kumud ;
Pleass, Henry .
TRANSPLANTATION, 2016, 100 (07) :1513-1524
[5]   The influence of functional warm ischemia time on DCD liver transplant recipients' outcomes [J].
Coffey, Jessica C. ;
Wanis, Kerollos N. ;
Monbaliu, Diethard ;
Gilbo, Nicholas ;
Selzner, Markus ;
Vachharajani, Neeta ;
Levstik, Mark A. ;
Marquez, Max ;
Doyle, Maria B. Majella ;
Pirenne, Jacques ;
Grant, David ;
Heimbach, Julie K. ;
Chapman, William ;
Vogt, Kelly ;
Hernandez-Alejandro, Roberto .
CLINICAL TRANSPLANTATION, 2017, 31 (10)
[6]   Improving National Results in Liver Transplantation Using Grafts From Donation After Cardiac Death Donors [J].
Croome, Kristopher P. ;
Lee, David D. ;
Keaveny, Andrew P. ;
Taner, C. Burcin .
TRANSPLANTATION, 2016, 100 (12) :2640-2647
[7]   Donors after cardiac death: Validation of identification criteria (DVIC) study for predictors of rapid death [J].
DeVita, M. A. ;
Brooks, M. Mori ;
Zawistowski, C. ;
Rudich, S. ;
Daly, B. ;
Chaitin, E. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2008, 8 (02) :432-441
[8]   Impact of Donor Hepatectomy Time During Organ Procurement in Donation After Circulatory Death Liver Transplantation: The United Kingdom Experience [J].
Farid, Shahid G. ;
Attia, Magdy S. ;
Vijayanand, Dhakshina ;
Upasani, Vivek ;
Barlow, Adam D. ;
Willis, Sean ;
Hidalgo, Ernest ;
Ahmad, Niaz .
TRANSPLANTATION, 2019, 103 (04) :E79-E88
[9]   Biliary Complications After Liver Transplantation From Donation After Cardiac Death Donors An Analysis of Risk Factors and Long-term Outcomes From a Single Center [J].
Foley, David P. ;
Fernandez, Luis A. ;
Leverson, Glen ;
Anderson, Michael ;
Mezrich, Joshua ;
Sollinger, Hans W. ;
D'Alessandro, Anthony .
ANNALS OF SURGERY, 2011, 253 (04) :817-825
[10]   Variability in Donation After Cardiac Death Protocols: A National Survey [J].
Fugate, Jennifer E. ;
Stadtler, Maria ;
Rabinstein, Alejandro A. ;
Wijdicks, Eelco F. M. .
TRANSPLANTATION, 2011, 91 (04) :386-389