Boron neutron capture therapy: Current status and future perspectives

被引：200

作者：

Dymova, Mayya Alexandrovna ^{[1
]}

Taskaev, Sergey Yurjevich ^{[2
,3
]}

Richter, Vladimir Alexandrovich ^{[1
]}

Kuligina, Elena Vladimirovna ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Lab Biotechnol, Siberian Branch, Lavrentjeva Av 8, Novosibirsk 630090, Russia

[2] Russian Acad Sci, Budker Inst Nucl Phys, Siberian Branch, Lavrentjeva Av 11, Novosibirsk 630090, Russia

[3] Novosibirsk State Univ, Lab Boron Neutron Capture Therapy, Pirogova Str 1, Novosibirsk 630090, Russia

来源：

CANCER COMMUNICATIONS | 2020年 / 40卷 / 09期

基金：

俄罗斯科学基金会;

关键词：

boron compounds; Boron neutron capture therapy; cancer treatment; cancer; drug delivery; SQUAMOUS-CELL CARCINOMA; MALIGNANT PLEURAL MESOTHELIOMA; BLOOD-BRAIN-BARRIER; RECURRENT HEAD; EPITHERMAL NEUTRON; CLINICAL-TRIAL; NECK-CANCER; DNA-DAMAGE; IN-VITRO; BNCT;

D O I：

10.1002/cac2.12089

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The development of new accelerators has given a new impetus to the development of new drugs and treatment technologies using boron neutron capture therapy (BNCT). We analyzed the current status and future directions of BNCT for cancer treatment, as well as the main issues related to its introduction. This review highlights the principles of BNCT and the key milestones in its development: new boron delivery drugs and different types of charged particle accelerators are described; several important aspects of BNCT implementation are discussed. BCNT could be used alone or in combination with chemotherapy and radiotherapy, and it is evaluated in light of the outlined issues. For the speedy implementation of BCNT in medical practice, it is necessary to develop more selective boron delivery agents and to generate an epithermal neutron beam with definite characteristics. Pharmacological companies and research laboratories should have access to accelerators for large-scale screening of new, more specific boron delivery agents.

引用

页码：406 / 421

页数：16

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