The Current Drug Treatment Landscape for Diabetes and Perspectives for the Future

被引：73
作者：
Bailey, C. J. [1 ]
机构：
[1] Aston Univ, Sch Life & Hlth Sci, Birmingham B4 7ET, W Midlands, England
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2015年 / 98卷 / 02期
关键词：
GLP-1 RECEPTOR AGONISTS; TYPE-2; INHIBITORS; THERAPY; MANAGEMENT; METFORMIN; OBESITY; PATHOPHYSIOLOGY; ASSOCIATION; EFFICACY;
D O I：
10.1002/cpt.144
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The escalating global epidemic of type 2 diabetes mellitus has focused attention on the devastating consequences of protracted hyperglycemia. Early and effective intervention to control blood glucose is a fundamental principle of treatment guidelines, requiring assiduous use of current therapies. However, many patients do not achieve or maintain glycemic targets, emphasizing the need for further therapies. This narrative review assesses the available medicinal options to address hyperglycemia and the opportunities to develop novel agents.
引用
收藏
页码：170 / 184
页数：15
相关论文
共 48 条
[1]   New hepatic targets for glycaemic control in diabetes [J].
Agius, Loranne .
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 21 (04) :587-605
[2]   Introduction [J].
不详 .
DIABETES CARE, 2015, 38 :S1-S2
[3]   Efficacy of GLP-1 Receptor Agonists and DPP-4 Inhibitors: Meta-Analysis and Systematic Review [J].
Aroda, Vanita R. ;
Henry, Robert R. ;
Han, Jenny ;
Huang, Wenying ;
DeYoung, Mary Beth ;
Darsow, Tamara ;
Hoogwerf, Byron J. .
CLINICAL THERAPEUTICS, 2012, 34 (06) :1247-1258
[4]   Glucagon antagonism as a potential therapeutic target in type 2 diabetes [J].
Bagger, J. I. ;
Knop, F. K. ;
Holst, J. J. ;
Vilsboll, T. .
DIABETES OBESITY & METABOLISM, 2011, 13 (11) :965-971
[5]   Biology of incretins: GLP-1 and GIP [J].
Baggio, Laurie L. ;
Drucker, Daniel J. .
GASTROENTEROLOGY, 2007, 132 (06) :2131-2157
[6]  
Bailey C.J., 2015, CLIN PHARM THER
[7]  
Bailey C.J., 2011, OXFORD TXB ENDOCRINO, P1779
[8]   Drug therapy - Metformin [J].
Bailey, CJ ;
Turner, RC .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (09) :574-579
[9]  
Bailey Clifford J, 2007, Diab Vasc Dis Res, V4, P20, DOI 10.3132/dvdr.2007.002
[10]   Metformin: Effects on micro and macrovascular complications in type 2 diabetes [J].
Bailey, Clifford J. .
CARDIOVASCULAR DRUGS AND THERAPY, 2008, 22 (03) :215-224
12345