Antibacterial metabolites from the Sri Lankan demosponge-derived fungus, Aspergillus flavipes

被引：12

作者：

Ratnaweera, Pamoda B. ^{[1
,2
,3
,4
]}

Williams, David E. ^{[2
,3
]}

de Silva, E. Dilip ^{[1
]}

Andersen, Raymond J. ^{[2
,3
]}

机构：

[1] Univ Colombo, Dept Chem, Colombo 03, Sri Lanka

[2] Univ British Columbia, Dept Chem, Vancouver, BC, Canada

[3] Univ British Columbia, Dept Earth Ocean & Atmospher Sci, Vancouver, BC, Canada

[4] Uva Wellassa Univ, Dept Sci & Technol, Badulla, Sri Lanka

来源：

CURRENT SCIENCE | 2016年 / 111卷 / 09期

基金：

加拿大自然科学与工程研究理事会;

关键词：

Aspergillus flavipes; aspochalasin; asperphenamate; demosponge; marine; MARINE NATURAL-PRODUCTS; MICROORGANISMS; CYTOCHALASINS; DERIVATIVES; SPONGES;

D O I：

10.18520/cs/v111/i9/1473-1479

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Sri Lankan sponge-derived fungi are an unexploited resource awaiting exploration for drug leads. Three fungi from the internal tissues of a demosponge collected on the west coast of Sri Lanka were isolated and antimicrobial activities of their crude extracts were evaluated. Aspochalasin B, D, M, asperphenamate and 4-OMe asperphenamate were isolated from the crude ethyl acetate extract of the fungus Aspergillus flavipes. Aspochalasin B and D showed antibacterial activities against Bacillus subtilis (MIC, 16 and 32 mu g ml(-1) respectively), Staphylococcus aureus and MRSA (MIC, 32 mu g ml(-1)). The results highlight the potential of isolating bioactive secondary metabolites from Sri Lankan sponge-derived fungi.

引用

页码：1473 / 1479

页数：7

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