Polysaccharides as Cell Carriers for Tissue Engineering: the Use of Cellulose in Vascular Wall Reconstruction

被引:91
作者
Bacakova, L. [1 ]
Novotna, K. [1 ]
Parizek, M. [1 ]
机构
[1] Acad Sci Czech Republ, Inst Physiol, Dept Biomat & Tissue Engn, CR-14220 Prague 4, Czech Republic
关键词
Natural polymers; Bioartificial tissue replacements; Cell carriers; Cell therapy; Regenerative medicine; MESENCHYMAL STEM-CELLS; VIVO BIOCOMPATIBILITY EVALUATION; HYALURONIC-ACID HYDROGELS; FIBER-MESH SCAFFOLDS; HEART-VALVE LEAFLET; IN-VITRO EVALUATION; BACTERIAL CELLULOSE; GROWTH-FACTOR; ENDOTHELIAL-CELLS; PROGENITOR CELLS;
D O I
10.33549/physiolres.932644
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Polysaccharides are long carbohydrate molecules of monosaccharide units joined together by glycosidic bonds. These biological polymers have emerged as promising materials for tissue engineering due to their biocompatibility, mostly good availability and tailorable properties. This complex group of biomolecules can be classified using several criteria, such as chemical composition (homo- and heteropolysaccharides), structure (linear and branched), function in the organism (structural, storage and secreted polysaccharides), or source (animals, plants, microorganisms). Polysaccharides most widely used in tissue engineering include starch, cellulose, chitosan, pectins, alginate, agar, dextran, pullulan, gellan, xanthan and glycosaminoglycans. Polysaccharides have been applied for engineering and regeneration of practically all tissues, though mostly at the experimental level. Polysaccharides have been tested for engineering of blood vessels, myocardium, heart valves, bone, articular and tracheal cartilage, intervertebral discs, menisci, skin, liver, skeletal muscle, neural tissue, urinary bladder, and also for encapsulation and delivery of pancreatic islets and ovarian follicles. For these purposes, polysaccharides have been applied in various forms, such as injectable hydrogels or porous and fibrous scaffolds, and often in combination with other natural or synthetic polymers or inorganic nanoparticles. The immune response evoked by polysaccharides is usually mild, and can be reduced by purifying the material or by choosing appropriate crosslinking agents.
引用
收藏
页码:S29 / S47
页数:19
相关论文
共 156 条
[1]   Influence of polysaccharide composition on the biocompatibility of pullulan/dextran-based hydrogels [J].
Abed, Aicha ;
Assoul, Nabila ;
Ba, Maguette ;
Derkaoui, Sidi Mohamed ;
Portes, Patrick ;
Louedec, Liliane ;
Flaud, Patrice ;
Bataille, Isabelle ;
Letourneur, Didier ;
Meddahi-Pelle, Anne .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2011, 96A (03) :535-542
[2]   Electrostatic encapsulation and growth of plant cell cultures in alginate [J].
Al-Hajry, HA ;
Al-Maskry, SA ;
Al-Kharousi, LM ;
El-Mardi, O ;
Shayya, WH ;
Goosen, MFA .
BIOTECHNOLOGY PROGRESS, 1999, 15 (04) :768-774
[3]   Behavior of human chondrocytes in engineered porous bacterial cellulose scaffolds [J].
Andersson, Jessica ;
Stenhamre, Hanna ;
Backdahl, Henrik ;
Gatenholm, Paul .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2010, 94A (04) :1124-1132
[4]   Mechanical properties of bacterial cellulose and interactions with smooth muscle cells [J].
Bäckdahl, H ;
Helenius, G ;
Bodin, A ;
Nannmark, U ;
Johansson, BR ;
Risberg, B ;
Gatenholm, P .
BIOMATERIALS, 2006, 27 (09) :2141-2149
[5]   Engineering microporosity in bacterial cellulose scaffolds [J].
Backdahl, Henrik ;
Esguerra, Maricris ;
Delbro, Dick ;
Risberg, Bo ;
Gatenholm, Paul .
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2008, 2 (06) :320-330
[6]   Polysaccharide-Modified Synthetic Polymeric Biomaterials [J].
Baldwin, Aaron D. ;
Kiick, Kristi L. .
BIOPOLYMERS, 2010, 94 (01) :128-140
[7]   The influence of hydrogel modulus on the proliferation and differentiation of encapsulated neural stem cells [J].
Banerjee, Akhilesh ;
Arha, Manish ;
Choudhary, Soumitra ;
Ashton, Randolph S. ;
Bhatia, Surita R. ;
Schaffer, David V. ;
Kane, Ravi S. .
BIOMATERIALS, 2009, 30 (27) :4695-4699
[8]   Construction of a Portal Implantable Functional Tissue-Engineered Liver Using Perfusion-Decellularized Matrix and Hepatocytes in Rats [J].
Bao, Ji ;
Shi, Yujun ;
Sun, Huaiqiang ;
Yin, Xiangli ;
Yang, Ruina ;
Li, Li ;
Chen, Xi ;
Bu, Hong .
CELL TRANSPLANTATION, 2011, 20 (05) :753-766
[9]   Agar/collagen membrane as skin dressing for wounds [J].
Bao, Lei ;
Yang, Wei ;
Mao, Xuan ;
Mou, Shansong ;
Tang, Shunqing .
BIOMEDICAL MATERIALS, 2008, 3 (04)
[10]   HYDROGEL-BASED 3-DIMENSIONAL MATRIX FOR NEURAL CELLS [J].
BELLAMKONDA, R ;
RANIERI, JP ;
BOUCHE, N ;
AEBISCHER, P .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1995, 29 (05) :663-671