Viewing the Bilayer Hydrocarbon Core Using Neutron Diffraction

被引：5

作者：

Han, Xue ^{[1
]}

Hristova, Kalina ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

来源：

JOURNAL OF MEMBRANE BIOLOGY | 2009年 / 227卷 / 03期

关键词：

Membrane structure; Membrane biophysics; Biophysical techniques in membrane research; X-RAY-DIFFRACTION; RESONANCE ENERGY-TRANSFER; LIPID-BILAYERS; MEMBRANE INTERFACE; JOINT REFINEMENT; FLUID BILAYERS; DOUBLE-BONDS; DIOLEOYLPHOSPHATIDYLCHOLINE; HELIX; CONSEQUENCES;

D O I：

10.1007/s00232-008-9151-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane proteins fold, assemble and function within their native fluid lipid environment. Structural studies of fluid lipid bilayers are thus critically important for understanding processes in membranes. Here, we propose a simple approach to visualize the hydrocarbon core using neutron diffraction and deuterated lipids that are commercially available. This method should have broad utility in structural studies of the bilayer response to protein insertion and folding in membranes.

引用

页码：123 / 131

页数：9

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