Caspofungin susceptibility in Aspergillus and non-Aspergillus molds:: Inhibition of glucan synthase and reduction of β-D-1,3 glucan levels in culture

被引：52

作者：

Kahn, JN ^{[1
]}

Hsu, MJ ^{[1
]}

Racine, F ^{[1
]}

Giacobbe, R ^{[1
]}

Motyl, M ^{[1
]}

机构：

[1] Merck & Co Inc, Infect Dis Res, Rahway, NJ 07065 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 06期

关键词：

D O I：

10.1128/AAC.01610-05

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Caspofungin inhibits synthesis of beta-D-1,3 glucan, essential to cell walls in Candida and Aspergillus spp., but activity against less common molds is largely uncharacterized. We demonstrate that caspofungin inhibits beta-D-1,3 glucan synthesis and reduces in vitro growth of clinical isolates from the genera Alternaria, Curvularia, Scedosporium, Acremonium, Bipolaris, and Trichoderma.

引用

页码：2214 / 2216

页数：3

共 7 条

[1] Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi
Diekema, DJ
Messer, SA
Hollis, RJ
Jones, RN
Pfaller, MA
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (08) : 3623 - 3626
[2] Isolation of a gene involved in 1,3-beta-glucan synthesis in Aspergillus nidulans and purification of the corresponding protein
Kelly, R
Register, E
Hsu, MJ
Kurtz, M
Nielsen, J
[J]. JOURNAL OF BACTERIOLOGY, 1996, 178 (15) : 4381 - 4391
[3] NCCLS (National Committee for Clinical Laboratory Standards), 2002, M38A NCCLS
[4] In vitro activity of anidulafungin against selected clinically important mold isolates
Odabasi, Z
Paetznick, VL
Rodriguez, JR
Chen, E
Ostrosky-Zeichner, L
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (05) : 1912 - 1915
[5] Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp isolates
Park, S
Kelly, R
Kahn, JN
Robles, J
Hsu, MJ
Register, E
Li, W
Vyas, V
Fan, H
Abruzzo, G
Flattery, A
Gill, C
Chrebet, G
Parent, SA
Kurtz, A
Teppler, H
Douglas, CA
Perlin, DS
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (08) : 3264 - 3273
[6] Rare and emerging opportunistic fungal pathogens:: Concern for resistance beyond Candida albicans and Aspergillus fumigatus
Pfaller, MA
Diekema, DJ
[J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (10) : 4419 - 4431
[7] A microtiter-based fluorescence assay for (1,3)-beta-glucan synthases
Shedletzky, E
Unger, C
Delmer, DP
[J]. ANALYTICAL BIOCHEMISTRY, 1997, 249 (01) : 88 - 93

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