Molecular targeting therapy for pancreatic cancer: current knowledge and perspectives from bench to bedside

被引：38
作者：
Furukawa, Toru [1 ]
机构：
[1] Tokyo Womens Med Univ, Int Res & Educ Inst Integrated Med Sci, Shinjuku Ku, Tokyo 1628666, Japan
来源：
JOURNAL OF GASTROENTEROLOGY | 2008年 / 43卷 / 12期
关键词：
pancreatic cancer; molecular targeting; RAS-MAPK; PI3K-AKT; hedgehog;
D O I：
10.1007/s00535-008-2226-1
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Current medical interventions for pancreatic cancer are insufficient. Recent molecular investigations have elucidated complex genetic mechanisms of cancer that especially involve multiple signal transduction pathways; this enables us to develop molecular medicines targeting specific genetic molecules in the pathways. These molecular medicines seem to promise clues for curing cancers, including pancreatic cancer. This review describes current knowledge and perspectives regarding the development of molecular medicines for pancreatic cancer by focusing on growth factor receptor systems and three major signal transduction pathways: the RAS-MAPK, PI3K-AKT-mTOR, and hedgehog pathways.
引用
收藏
页码：905 / 911
页数：7
相关论文
共 50 条
  • [31] Endoscopic ultrasonography for pancreatic cancer: current and future perspectives
    De Angelis, Claudio
    Brizzi, Rosario Francesco
    Pellicano, Rinaldo
    JOURNAL OF GASTROINTESTINAL ONCOLOGY, 2013, 4 (02) : 220 - 230
  • [32] Current Status of Adjuvant Therapy for Pancreatic Cancer
    Katz, Matthew H. G.
    Fleming, Jason B.
    Lee, Jeffrey E.
    Pisters, Peter W. T.
    ONCOLOGIST, 2010, 15 (11) : 1205 - 1213
  • [33] Current Controversies in Neoadjuvant Therapy for Pancreatic Cancer
    Ward, Erin P.
    Zeh, Herbert J., III
    Tsai, Susan
    SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA, 2021, 30 (04) : 657 - 671
  • [34] Neoadjuvant Therapy for Pancreatic Cancer: A Current Review
    Abbott, Daniel E.
    Baker, Marshall S.
    Talamonti, Mark S.
    JOURNAL OF SURGICAL ONCOLOGY, 2010, 101 (04) : 315 - 320
  • [35] Modelling Pancreatic Neuroendocrine Cancer: From Bench Side to Clinic
    Ney, Alexander
    Canciani, Gabriele
    Hsuan, J. Justin
    Pereira, Stephen P.
    CANCERS, 2020, 12 (11) : 1 - 20
  • [36] Targeting Notch to Eradicate Pancreatic Cancer Stem Cells for Cancer Therapy
    Wang, Zhiwei
    Ahmad, Aamir
    Li, Yiwei
    Azmi, Asfar S.
    Miele, Lucio
    Sarkar, Fazlul H.
    ANTICANCER RESEARCH, 2011, 31 (04) : 1105 - 1113
  • [37] Surgery for advanced and metastatic pancreatic cancer - Current state and perspectives
    Mann, O
    Strate, T
    Schneider, C
    Yekebas, EF
    Izbicki, JR
    ANTICANCER RESEARCH, 2006, 26 (1B) : 681 - 686
  • [38] Intratumoral Fusobacterium nucleatum in Pancreatic Cancer: Current and Future Perspectives
    D'Antonio, Domenica Lucia
    Zenoniani, Anna
    Umme, Samia
    Piattelli, Adriano
    Curia, Maria Cristina
    PATHOGENS, 2025, 14 (01):
  • [39] Molecular Pathogenesis and Targeted Therapy of Pancreatic Cancer
    Shinji Tanaka
    Annals of Surgical Oncology, 2016, 23 : 197 - 205
  • [40] Pancreatic cancer surgery with vascular resection: current concepts and perspectives
    ArturRebelo
    ChristophW.Michalski
    J?rgUkkat
    J?rgKleeff
    胰腺病学杂志（英文）, 2019, 2 (01) : 1 - 2-3-4-5
12345