Vibrational spectroscopic study of fluticasone propionate

被引：9
|
作者：
Ali, H. R. H. [1 ,3 ]
Edwards, H. G. M. [1 ]
Kendrick, J. [2 ]
Scowen, I. J. [1 ]
机构：
[1] Univ Bradford, Sch Life Sci, Univ Analyt Ctr, Bradford BD7 1DP, W Yorkshire, England
[2] Univ Bradford, Inst Pharmaceut Innovat, Bradford BD7 1DP, W Yorkshire, England
[3] Univ Assiut, Fac Pharm, Dept Pharmaceut Analyt Chem, Assiut, Egypt
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2009年 / 72卷 / 02期
关键词：
Raman spectroscopy; Infrared spectroscopy; Fluticasone propionate; Respiratory pharmaceuticals; Ab initio structural calculations; AMPHETAMINE; SILVER;
D O I：
10.1016/j.saa.2008.08.004
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Fluticasone propionate is a synthetic glucocorticoid with potent anti-inflammatory activity that has been used effectively in the treatment of chronic asthma. The present work reports a vibrational spectroscopic study of fluticasone propionate and gives proposed molecular assignments on the basis of ab initio calculations using BLYP density functional theory with a 6-31G* basis set and vibrational frequencies predicted within the quasi-harmonic approximation. Several spectral features and band intensities are explained. This study generated a library of information that can be employed to aid the process monitoring of fluticasone propionate. (c) 2008 Elsevier B.V. All rights reserved.
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页码：244 / 247
页数：4
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