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Aintree Univ Hosp NHS Fdn Trust, Dept Obes & Endocrinol, Inst Ageing & Chron Dis, Ctr Clin Sci, Liverpool L9 7AL, Merseyside, England Aintree Univ Hosp NHS Fdn Trust, Dept Obes & Endocrinol, Inst Ageing & Chron Dis, Ctr Clin Sci, Liverpool L9 7AL, Merseyside, England