Postsynaptic calcium signaling microdomains in neurons

被引：28
作者：
Blackstone, C
Sheng, M
机构：
[1] NINCDS, Cellular Neurol Unit, NIH, Bethesda, MD 20892 USA
[2] MIT, RIKEN MIT Neurosci Res Ctr, Ctr Learning & Memory, Cambridge, MA 02139 USA
来源：
FRONTIERS IN BIOSCIENCE | 2002年 / 7卷
关键词：
postsynaptic density; PDZ domain; dendritic spine; review; calcium; neuron;
D O I：
10.2741/blacksto
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Calcium ions are crucial messengers in the regulation of synaptic efficacy. In the postsynaptic neuron, this is exemplified by the tight temporal and spatial co-segregation of calcium ions with calcium-dependent signal transduction protein complexes in dendritic spines. Over the last several years optical imaging, physiological, structural, and biological studies have clarified the molecular mechanisms underlying differential calcium signaling within the spine. In this review, we discuss how calcium signaling "microdomains" are organized and regulated. We emphasize the structural and functional features of precisely regulated supramolecular complexes incorporating proteins involved in calcium influx, calcium efflux, and signal transduction. These complexes act in concert to orchestrate the sophisticated postsynaptic calcium signaling that underlies synaptic plasticity.
引用
收藏
页码：D872 / D885
页数：14
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共 110 条
  • [51] Rapid dendritic morphogenesis in CA1 hippocampal dendrites induced by synaptic activity
    Maletic-Savatic, M
    Malinow, R
    Svoboda, K
    [J]. SCIENCE, 1999, 283 (5409) : 1923 - 1927
  • [52] Selective activation of Ca2+-activated K+ channels by co-localized Ca2+ channels in hippocampal neurons
    Marrion, NV
    Tavalin, SJ
    [J]. NATURE, 1998, 395 (6705) : 900 - 905
  • [53] Enhanced long-term potentiation and impaired learning in mice with mutant postsynaptic density-95 protein
    Migaud, M
    Charlesworth, P
    Dempster, M
    Webster, LC
    Watabe, AM
    Makhinson, M
    He, Y
    Ramsay, MF
    Morris, RGM
    Morrison, JH
    O'Dell, TJ
    Grant, SGN
    [J]. NATURE, 1998, 396 (6710) : 433 - 439
  • [54] Local calcium release in dendritic spines required for long-term synaptic depression
    Miyata, M
    Finch, EA
    Khiroug, L
    Hashimoto, K
    Hayasaka, S
    Oda, SI
    Inouye, M
    Takagishi, Y
    Augustine, GJ
    Kano, M
    [J]. NEURON, 2000, 28 (01) : 233 - 244
  • [55] Shank, a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin
    Naisbitt, S
    Kim, E
    Tu, JC
    Xiao, B
    Sala, C
    Valtschanoff, J
    Weinberg, RJ
    Worley, PF
    Sheng, M
    [J]. NEURON, 1999, 23 (03) : 569 - 582
  • [56] Vesicle pools and Ca2+ microdomains:: New tools for understanding their roles in neurotransmitter release
    Neher, E
    [J]. NEURON, 1998, 20 (03) : 389 - 399
  • [57] Calcium stores regulate the polarity and input specificity of synaptic modfication
    Nishiyama, M
    Hong, K
    Mikoshiba, K
    Poo, M
    Kato, K
    [J]. NATURE, 2000, 408 (6812) : 584 - 588
  • [58] Continual remodeling of postsynaptic density and its regulation by synaptic activity
    Okabe, S
    Kim, HD
    Miwa, A
    Kuriu, T
    Okado, H
    [J]. NATURE NEUROSCIENCE, 1999, 2 (09) : 804 - 811
  • [59] Rapid redistribution of the postsynaptic density protein PSD-Zip45 (Homer 1c) and its differential regulation by NMDA receptors and calcium channels
    Okabe, S
    Urushido, T
    Konno, D
    Okado, H
    Sobue, K
    [J]. JOURNAL OF NEUROSCIENCE, 2001, 21 (24) : 9561 - 9571
  • [60] Regulation of dendritic spine morphology by SPAR, a PSD-95-associated RapGAP
    Pak, DTS
    Yang, SY
    Rudolph-Correia, S
    Kim, E
    Sheng, M
    [J]. NEURON, 2001, 31 (02) : 289 - 303
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