Controlled Release Scaffolds for Bone Tissue Engineering

被引：49

作者：

Cartmell, Sarah ^{[1
]}

机构：

[1] Keele Univ, Inst Sci & Technol Med, Med Res Unit, Stoke On Trent ST4 7QB, Staffs, England

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 2009年 / 98卷 / 02期

关键词：

bone tissue engineering; controlled release; growth factor; scaffold; delivery vehicle; protein delivery; biodegradable polymers; polymeric drug delivery systems; polymeric drug carrier; microencapsulation; FIBROBLAST-GROWTH-FACTOR; MANDIBULAR DISTRACTION OSTEOGENESIS; CONTROLLED LOCAL RELEASE; MARROW STROMAL CELLS; MORPHOGENETIC PROTEIN-2; DELIVERY-SYSTEM; IN-VITRO; SODIUM-FLUORIDE; COMPOSITE SCAFFOLDS; SUSTAINED DELIVERY;

D O I：

10.1002/jps.21431

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Bone disease and trauma can sometimes create defects that require more than current clinical therapies can provide for effective healing. Scaffolds that release bioactive agents such as drugs offer additional benefits in this regard in comparison to those whose main requirements are space filling and load bearing. This review details a variety of recent research on scaffold carrier systems that release osteogenic drugs for orthopaedic treatment purposes. The controlled release scaffolds presented are created from a variety of materials (such as tricalcium phosphate, hydrogel systems and poly(D,L-lactide)) and release drugs such as statins, bisphosphonates and a variety of growth factors. (C) 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:430-441, 2009

引用

页码：430 / 441

页数：12

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