Pyrrolizidine alkaloids from seven wild-growing Senecio species in Serbia and Montenegro

被引：12

作者：

Mandic, Boris M. ^{[1
]}

Godevac, Dejan N. ^{[2
]}

Beskoski, Vladimir P. ^{[2
]}

Simic, Milena R. ^{[3
]}

Trifunovic, Snezana S. ^{[2
]}

Tesevic, Vele V. ^{[1
]}

Vajs, Vlatka V. ^{[2
]}

Milosavljevic, Slobodan M. ^{[1
]}

机构：

[1] Fac Chem, Belgrade 11000, Serbia

[2] Univ Belgrade, Inst Chem Technol & Met, Belgrade 11000, Serbia

[3] Univ Belgrade, Fac Pharm, Belgrade 11000, Serbia

来源：

JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2009年 / 74卷 / 01期

关键词：

Senecio; pyrrolizidine alkaloids; antitumor and antimicrobial activity; NMR-SPECTROSCOPY; METABOLISM;

D O I：

10.2298/JSC0901027M

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The genus Senecio (family Asteraceae) is one of the largest in the world. It comprises about 1100 species which are the rich source of pyrrolizidine alkaloids. Plants containing pyrrolizidine alkaloids are among the most important sources of human and animal exposure to plant toxins and carcinogens. The pyrrolizidine alkaloids of seven Senecio species (S. erucifolius, S. othonnae, S. wagneri, S. subalpinus, S. carpathicus, S. paludosus and S. rupestris) were studied. Fourteen alkaloids were isolated and their structures determined from spectroscopic data (H-1- and C-13-NMR, IR and MS). Five of them were identified in S. erucifolius, four in S. othonnae, two in S. wagneri, four in S. subalpinus, two in S. carpathicus, three in S. paludosus and three in S. rupestris. Seven pyrrolizidine alkaloids were found for the first time in particular species. The results have chemotaxonomic importance. The cytotoxic activity and antimicrobial activity of some alkaloids were also studied.

引用

页码：27 / 34

页数：8