Interferon-β gene transfer inhibits melanoma cells adhesion and migration
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作者:
Rossi, Ursula A.
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Univ Buenos Aires, Unidad Transferencia Genet, Inst Oncol Angel H Roffo, Ave San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Unidad Transferencia Genet, Inst Oncol Angel H Roffo, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Rossi, Ursula A.
[1
]
Finocchiaro, Liliana M. E.
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Univ Buenos Aires, Unidad Transferencia Genet, Inst Oncol Angel H Roffo, Ave San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Unidad Transferencia Genet, Inst Oncol Angel H Roffo, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Finocchiaro, Liliana M. E.
[1
]
Glikin, Gerardo C.
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Univ Buenos Aires, Unidad Transferencia Genet, Inst Oncol Angel H Roffo, Ave San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Unidad Transferencia Genet, Inst Oncol Angel H Roffo, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Glikin, Gerardo C.
[1
]
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[1] Univ Buenos Aires, Unidad Transferencia Genet, Inst Oncol Angel H Roffo, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
We evaluated the effects of expression of interferon-beta (IFN beta) after lipofection on melanoma cells adhesion and migration. Three canine mucosal (Ak, Br and Ol) and one human dermal (SB2) melanomas were assayed. By means of the wound healing assay, we found a significant inhibitory effect of canine IFN beta gene expression on cells migration in Br and Ol monolayers. This effect could be reproduced on unlipo-fected Ol cells with conditioned culture media obtained from canine IFN beta gene-lipofected Ol cells, and with recombinant human IFN beta on unlipofected SB2 cells. Furthermore, IFN beta gene expression of the four tested tumor cells significantly inhibited their adhesion to extracellular matrix (ECM) proteins and their spreading from multicellular spheroids onto gelatin coating. The addition of catalase reverted the increase of reactive oxygen species (ROS) in Ol cells and the inhibition of cell migration in monolayers (Ol) and spheroids (Ol an SB2) produced by canine and human IFN beta expression, suggesting the involvement of ROS as mediators of IFN beta action on the cells interactions with ECM. Together with its known immune, antiangiogenic and cytotoxic effects, the present data strongly support more studies exploring the clinical potential of IFN beta for cancer therapy. (C) 2015 Elsevier Ltd. All rights reserved.
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Univ Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Av San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Av San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Rossi, Ursula A.
Finocchiaro, Liliana M. E.
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Univ Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Av San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Av San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Finocchiaro, Liliana M. E.
Glikin, Gerardo C.
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Univ Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Av San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Av San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
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Univ Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Fondello, Chiara
Agnetti, Lucrecia
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Univ Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Agnetti, Lucrecia
Villaverde, Marcela S.
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Univ Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Villaverde, Marcela S.
Simian, Marina
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Univ Nacl San Martin, Inst Nanosistemas, Buenos Aires, DF, Argentina
Univ Nacl San Martin, CEDESI, Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Simian, Marina
Glikin, Gerardo C.
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Univ Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
Glikin, Gerardo C.
Finocchiaro, Liliana M. E.
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Univ Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, ArgentinaUniv Buenos Aires, Inst Oncol Angel H Roffo, Unidad Transferencia Genet, Ave San Martin 5481, RA-1417 Buenos Aires, DF, Argentina
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Univ No Colorado, Sch Biol Sci, 501 20th St,CB 92, Greeley, CO 80639 USA
Weill Cornell Med, Dept Pharmacol, 1300 York Ave, New York, NY 10065 USAUniv No Colorado, Sch Biol Sci, 501 20th St,CB 92, Greeley, CO 80639 USA
Saviola, Anthony J.
Burns, Patrick D.
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Univ No Colorado, Sch Biol Sci, 501 20th St,CB 92, Greeley, CO 80639 USAUniv No Colorado, Sch Biol Sci, 501 20th St,CB 92, Greeley, CO 80639 USA
Burns, Patrick D.
Mukherjee, Ashis K.
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Univ No Colorado, Sch Biol Sci, 501 20th St,CB 92, Greeley, CO 80639 USA
Tezpur Univ, Dept Mol Biol & Biotechnol, Microbial Biotechnol & Prot Res Lab, Tezpur 784028, Assam, IndiaUniv No Colorado, Sch Biol Sci, 501 20th St,CB 92, Greeley, CO 80639 USA
Mukherjee, Ashis K.
Mackessy, Stephen P.
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Univ No Colorado, Sch Biol Sci, 501 20th St,CB 92, Greeley, CO 80639 USAUniv No Colorado, Sch Biol Sci, 501 20th St,CB 92, Greeley, CO 80639 USA
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Prov Blood Ctr, Nanchang 330052, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Shi, Meng-Lin
Chen, Yu-Fen
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R China
Nanchang Univ, Dept Ophthalmol, Affiliated Eye Hosp, Nanchang 330000, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Chen, Yu-Fen
Wu, Wei-Qi
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R China
Nanchang Univ, Dept Ophthalmol, Affiliated Eye Hosp, Nanchang 330000, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Wu, Wei-Qi
Lai, Yao
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R China
Nanchang Univ, Dept Ophthalmol, Affiliated Eye Hosp, Nanchang 330000, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Lai, Yao
Jin, Qi
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R China
Nanchang Univ, Dept Ophthalmol, Affiliated Eye Hosp, Nanchang 330000, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jin, Qi
Qiu, Wan-Lu
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R China
Nanchang Univ, Dept Ophthalmol, Affiliated Eye Hosp, Nanchang 330000, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Qiu, Wan-Lu
Yu, Dong-Lian
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R China
Nanchang Univ, Dept Ophthalmol, Affiliated Eye Hosp, Nanchang 330000, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Yu, Dong-Lian
Li, Yi-Zhong
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R China
Nanchang Univ, Dept Ophthalmol, Affiliated Eye Hosp, Nanchang 330000, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Li, Yi-Zhong
Liao, Hong-Fei
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Nanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
Jiangxi Res Inst Ophthalmol & Visual Sci, Nanchang 330006, Jiangxi, Peoples R China
Nanchang Univ, Dept Ophthalmol, Affiliated Eye Hosp, Nanchang 330000, Jiangxi, Peoples R ChinaNanchang Univ, Nanchang 330000, Jiangxi, Peoples R China
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Tianjin Med Univ, Dept Pathol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Sun, Tao
Zhao, Nan
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Tianjin Med Univ, Dept Pathol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Zhao, Nan
Ni, Chun-sheng
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Tianjin Med Univ, Dept Pathol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Ni, Chun-sheng
Zhao, Xiu-lan
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Tianjin Med Univ, Dept Pathol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Zhao, Xiu-lan
Zhang, Wen-zhi
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Tianjin Huan Hu Hosp, Dept Cell Biol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Zhang, Wen-zhi
Su, Xin
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Tianjin Huan Hu Hosp, Dept Cell Biol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Su, Xin
Zhang, Dan-fang
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Tianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Tianjin Med Univ, Dept Pathol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Zhang, Dan-fang
Gu, Qiang
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Tianjin Med Univ, Dept Pathol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Gu, Qiang
Sun, Bao-cun
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Tianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
Tianjin Med Univ, Dept Pathol, Tianjin 300070, Peoples R ChinaTianjin Med Univ, Dept Pathol, Tianjin Canc Hosp, Tianjin 300070, Peoples R China
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Guangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China
Guangdong Med Univ, Inst Biochem & Mol Biol, Zhanjiang, Peoples R ChinaGuangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China
Liu, Weixian
Huang, Xinxian
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Guangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China
Guangdong Med Univ, Sch Med Technol, Dongguan, Peoples R ChinaGuangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China
Huang, Xinxian
Luo, Weizhao
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Guangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China
Guangdong Med Univ, Inst Biochem & Mol Biol, Zhanjiang, Peoples R ChinaGuangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China
Luo, Weizhao
Liu, Xinguang
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Guangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China
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Liu, Xinguang
Chen, Weichun
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Guangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China
Guangdong Med Univ, Inst Biochem & Mol Biol, Zhanjiang, Peoples R ChinaGuangdong Med Univ, Inst Aging Res, Guangdong Prov Key Lab Med Mol Diagnost, Dongguan, Peoples R China