Targeting TFIIH to inhibit host cell transcription by Rift Valley Fever Virus

被引：15
作者：
Dasgupta, A [1 ]
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Microbiol Immunol & Mol Genet, Los Angeles, CA 90095 USA
来源：
MOLECULAR CELL | 2004年 / 13卷 / 04期
关键词：
D O I：
10.1016/S1097-2765(04)00092-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the February 20 issue of Cell, Le May et al. (2004) report that Rift Valley Fever Virus (RVFV) targets cellular transcriptional apparatus to inhibit RNA polymerase II-mediated transcription. Unlike polio and vesicular stomatitis viruses, both of which target the TATA binding protein (TBP), RVFV appears to target the basal transcription factor THIIH to induce shut-off of host cell transcription.
引用
收藏
页码：456 / 458
页数：3
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