Serum Anti-Mullerian Hormone Levels in Healthy Females: A Nomogram Ranging from Infancy to Adulthood

被引:198
作者
Fong, S. Lie [1 ]
Visser, J. A. [2 ]
Welt, C. K. [5 ]
de Rijke, Y. B. [3 ]
Eijkemans, M. J. C. [6 ]
Broekmans, F. J. [7 ]
Roes, E. M. [4 ]
Peters, W. H. M. [8 ]
Hokken-Koelega, A. C. S. [9 ]
Fauser, B. C. J. M. [7 ]
Themmen, A. P. N. [2 ]
de Jong, F. H. [2 ]
Schipper, I. [1 ]
Laven, J. S. E. [1 ]
机构
[1] Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands
[2] Univ Med Ctr, Dept Internal Med, Erasmus Med Ctr, NL-3000 CA Rotterdam, Netherlands
[3] Univ Med Ctr, Dept Clin Chem, Erasmus Med Ctr, NL-3000 CA Rotterdam, Netherlands
[4] Univ Med Ctr, Div Gynecol Oncol, Erasmus Med Ctr, Dept Obstet & Gynecol, NL-3000 CA Rotterdam, Netherlands
[5] Massachusetts Gen Hosp, Reprod Endocrine Unit, Boston, MA 02114 USA
[6] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands
[7] Univ Med Ctr Utrecht, Div Reprod Med, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands
[8] Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol, NL-6500 HB Nijmegen, Netherlands
[9] Sophia Childrens Univ Hosp, Erasmus MC, Div Endocrinol, Dept Pediat, NL-3000 CB Rotterdam, Netherlands
关键词
POLYCYSTIC-OVARY-SYNDROME; FOLLICLE-STIMULATING-HORMONE; ANTIMULLERIAN HORMONE; NORMAL WOMEN; PROVEN FERTILITY; INHIBIN-B; AGE; PREVALENCE; MARKER; POPULATION;
D O I
10.1210/jc.2012-1440
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Context: Anti-Mullerian hormone (AMH) is an accurate marker of ovarian reserve. However, sufficiently large sets of normative data from infancy to the end of reproductive life are scarce. Objective: This study was an assessment of serum AMH levels in healthy females. Subjects: In 804 healthy females ranging from infancy until the end of the reproductive period, serum AMH levels were measured with an enzyme-linked immunometric assay. All adults had regular menstrual cycles. The majority was proven fertile and none of them had used oral contraceptive pills prior to study inclusion. Results: In the total cohort, AMH was inversely correlated with age (r = -0.24; P < 0.001). The age at which the maximum AMH value was attained was at 15.8 yr. In girls younger than 15.8 yr, serum AMH and age were positively correlated (r = +0.18; P = 0.007). Thereafter AMH levels remained stable (r = -0.33; P = 0.66), whereas from the age of 25.0 yr onward, an inverse correlation between AMH and age (r = -0.47; P < 0.001) was observed. At any given age, considerable interindividual differences in serum AMH levels were observed. Conclusion: During infancy AMH levels increase, whereas during adolescence, a plateau until the age of 25 yr was observed. From the age of 25 yr onward, serum AMH levels correlate inversely with age, implying that AMH is applicable as a marker of ovarian reserve only in women of 25 yr old and older. Our nomogram may facilitate counseling women on their reproductive potential. (J Clin Endocrinol Metab 97: 4650-4655, 2012)
引用
收藏
页码:4650 / 4655
页数:6
相关论文
共 38 条
[1]   Polycystic ovarian morphology with regular ovulatory cycles: Insights into the pathophysiology of polycystic ovarian syndrome [J].
Adams, JM ;
Taylor, AE ;
Crowley, WF ;
Hall, JE .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (09) :4343-4350
[2]   Age-related normograms of serum antimullerian hormone levels in a population of infertile women: a multicenter study [J].
Almog, Benny ;
Shehata, Fady ;
Suissa, Sami ;
Holzer, Hananel ;
Shalom-Paz, Einat ;
La Marca, Antonio ;
Muttukrishna, Shanthi ;
Blazar, Andrew ;
Hackett, Richard ;
Nelson, Scott M. ;
Cunha-Filho, Joao Sabino ;
Eldar-Geva, Talia ;
Margalioth, Ehud J. ;
Raine-Fenning, Nick ;
Jayaprakasan, Kannamannadiar ;
McIlveen, Myvanwy ;
Wunder, Dorothea ;
Freour, Thomas ;
Nardo, Luciano G. ;
Balasch, Juan ;
Penarrubia, Joana ;
Smeenk, Jesper ;
Gnoth, Christian ;
Godehardt, Erhard ;
Lee, Tsung-Hsien ;
Lee, Maw-Sheng ;
Levin, Ishai ;
Gamzu, Ronni ;
Tulandi, Togas .
FERTILITY AND STERILITY, 2011, 95 (07) :2359-U280
[3]   Estradiol and regulation of anti-Mullerian hormone, inhibin-A, and inhibin-B secretion: Analysis of small antral and preovulatory human follicles' fluid [J].
Andersen, Claus Yding ;
Byskov, Anne Grete .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (10) :4064-4069
[4]   The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report [J].
Azziz, Ricardo ;
Carmina, Enrico ;
Dewailly, Didier ;
Diamanti-Kandarakis, Evanthia ;
Escobar-Morreale, Hector F. ;
Futterweit, Walter ;
Janssen, Onno E. ;
Legro, Richard S. ;
Norman, Robert J. ;
Taylor, Ann E. ;
Witchel, Selina F. .
FERTILITY AND STERILITY, 2009, 91 (02) :456-488
[5]   PCOS according to the Rotterdam consensus criteria: change in prevalence among WHO-II anovulation and association with metabolic factors [J].
Broekmans, F. J. ;
Knauff, E. A. H. ;
Valkenburg, O. ;
Laven, J. S. ;
Eijkemans, M. J. ;
Fauser, B. C. J. M. .
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2006, 113 (10) :1210-1217
[6]   Anti-Mullerian hormone and ovarian dysfunction [J].
Broekmans, Frank J. ;
Visser, Jenny A. ;
Laven, Joop S. E. ;
Broer, Simone L. ;
Themmen, Axel P. N. ;
Fauser, Bart C. .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2008, 19 (09) :340-347
[7]   Anti-Mullerian Hormone Predicts Menopause: A Long-Term Follow-Up Study in Normoovulatory Women [J].
Broer, S. L. ;
Eijkemans, M. J. C. ;
Scheffer, G. J. ;
van Rooij, I. A. J. ;
de Vet, A. ;
Themmen, A. P. N. ;
Laven, J. S. E. ;
de Jong, F. H. ;
Velde, E. R. Te ;
Fauser, B. C. ;
Broekmans, F. J. M. .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (08) :2532-2539
[8]   AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis [J].
Broer, S. L. ;
Dolleman, M. ;
Opmeer, B. C. ;
Fauser, B. C. ;
Mol, B. W. ;
Broekmans, F. J. M. .
HUMAN REPRODUCTION UPDATE, 2011, 17 (01) :46-54
[9]   The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count [J].
Broer, Simtone L. ;
Mol, Ben Willem J. ;
Hendriks, Dave ;
Broekmans, Frank J. M. .
FERTILITY AND STERILITY, 2009, 91 (03) :705-714
[10]   Antimullerian hormone serum levels: a putative marker for ovarian aging [J].
de Vet, A ;
Laven, JSE ;
de Jong, FH ;
Themmen, APN ;
Fauser, BCJM .
FERTILITY AND STERILITY, 2002, 77 (02) :357-362