共 38 条
Serum Anti-Mullerian Hormone Levels in Healthy Females: A Nomogram Ranging from Infancy to Adulthood
被引:198
作者:

Fong, S. Lie
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机构:
Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Visser, J. A.
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h-index: 0
机构:
Univ Med Ctr, Dept Internal Med, Erasmus Med Ctr, NL-3000 CA Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Welt, C. K.
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h-index: 0
机构:
Massachusetts Gen Hosp, Reprod Endocrine Unit, Boston, MA 02114 USA Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

de Rijke, Y. B.
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h-index: 0
机构:
Univ Med Ctr, Dept Clin Chem, Erasmus Med Ctr, NL-3000 CA Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Eijkemans, M. J. C.
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Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Broekmans, F. J.
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机构:
Univ Med Ctr Utrecht, Div Reprod Med, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Roes, E. M.
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Univ Med Ctr, Div Gynecol Oncol, Erasmus Med Ctr, Dept Obstet & Gynecol, NL-3000 CA Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Peters, W. H. M.
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机构:
Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol, NL-6500 HB Nijmegen, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Hokken-Koelega, A. C. S.
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机构:
Sophia Childrens Univ Hosp, Erasmus MC, Div Endocrinol, Dept Pediat, NL-3000 CB Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Fauser, B. C. J. M.
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机构:
Univ Med Ctr Utrecht, Div Reprod Med, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Themmen, A. P. N.
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机构:
Univ Med Ctr, Dept Internal Med, Erasmus Med Ctr, NL-3000 CA Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

de Jong, F. H.
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Univ Med Ctr, Dept Internal Med, Erasmus Med Ctr, NL-3000 CA Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Schipper, I.
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Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands

Laven, J. S. E.
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机构:
Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands
机构:
[1] Univ Med Ctr, Dept Obstet & Gynecol, Erasmus Med Ctr, Div Reprod Med, NL-3000 CA Rotterdam, Netherlands
[2] Univ Med Ctr, Dept Internal Med, Erasmus Med Ctr, NL-3000 CA Rotterdam, Netherlands
[3] Univ Med Ctr, Dept Clin Chem, Erasmus Med Ctr, NL-3000 CA Rotterdam, Netherlands
[4] Univ Med Ctr, Div Gynecol Oncol, Erasmus Med Ctr, Dept Obstet & Gynecol, NL-3000 CA Rotterdam, Netherlands
[5] Massachusetts Gen Hosp, Reprod Endocrine Unit, Boston, MA 02114 USA
[6] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands
[7] Univ Med Ctr Utrecht, Div Reprod Med, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands
[8] Radboud Univ Nijmegen, Med Ctr, Dept Gastroenterol, NL-6500 HB Nijmegen, Netherlands
[9] Sophia Childrens Univ Hosp, Erasmus MC, Div Endocrinol, Dept Pediat, NL-3000 CB Rotterdam, Netherlands
关键词:
POLYCYSTIC-OVARY-SYNDROME;
FOLLICLE-STIMULATING-HORMONE;
ANTIMULLERIAN HORMONE;
NORMAL WOMEN;
PROVEN FERTILITY;
INHIBIN-B;
AGE;
PREVALENCE;
MARKER;
POPULATION;
D O I:
10.1210/jc.2012-1440
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Context: Anti-Mullerian hormone (AMH) is an accurate marker of ovarian reserve. However, sufficiently large sets of normative data from infancy to the end of reproductive life are scarce. Objective: This study was an assessment of serum AMH levels in healthy females. Subjects: In 804 healthy females ranging from infancy until the end of the reproductive period, serum AMH levels were measured with an enzyme-linked immunometric assay. All adults had regular menstrual cycles. The majority was proven fertile and none of them had used oral contraceptive pills prior to study inclusion. Results: In the total cohort, AMH was inversely correlated with age (r = -0.24; P < 0.001). The age at which the maximum AMH value was attained was at 15.8 yr. In girls younger than 15.8 yr, serum AMH and age were positively correlated (r = +0.18; P = 0.007). Thereafter AMH levels remained stable (r = -0.33; P = 0.66), whereas from the age of 25.0 yr onward, an inverse correlation between AMH and age (r = -0.47; P < 0.001) was observed. At any given age, considerable interindividual differences in serum AMH levels were observed. Conclusion: During infancy AMH levels increase, whereas during adolescence, a plateau until the age of 25 yr was observed. From the age of 25 yr onward, serum AMH levels correlate inversely with age, implying that AMH is applicable as a marker of ovarian reserve only in women of 25 yr old and older. Our nomogram may facilitate counseling women on their reproductive potential. (J Clin Endocrinol Metab 97: 4650-4655, 2012)
引用
收藏
页码:4650 / 4655
页数:6
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Themmen, Axel P. N.
论文数: 0 引用数: 0
h-index: 0
机构:
Erasmus MC, Dept Internal Med, Rotterdam, Netherlands Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 6A Utrecht, Netherlands

Fauser, Bart C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 6A Utrecht, Netherlands Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 6A Utrecht, Netherlands
[7]
Anti-Mullerian Hormone Predicts Menopause: A Long-Term Follow-Up Study in Normoovulatory Women
[J].
Broer, S. L.
;
Eijkemans, M. J. C.
;
Scheffer, G. J.
;
van Rooij, I. A. J.
;
de Vet, A.
;
Themmen, A. P. N.
;
Laven, J. S. E.
;
de Jong, F. H.
;
Velde, E. R. Te
;
Fauser, B. C.
;
Broekmans, F. J. M.
.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,
2011, 96 (08)
:2532-2539

Broer, S. L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

Eijkemans, M. J. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands
Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

Scheffer, G. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

van Rooij, I. A. J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

de Vet, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Obstet & Gynecol, Div Reprod Med, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

Themmen, A. P. N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Div Endocrinol, Dept Internal Med, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

Laven, J. S. E.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Obstet & Gynecol, Div Reprod Med, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

de Jong, F. H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Div Endocrinol, Dept Internal Med, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

Velde, E. R. Te
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

Fauser, B. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands

Broekmans, F. J. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med & Gynecol, Div Woman & Baby, NL-3508 GA Utrecht, Netherlands
[8]
AMH and AFC as predictors of excessive response in controlled ovarian hyperstimulation: a meta-analysis
[J].
Broer, S. L.
;
Dolleman, M.
;
Opmeer, B. C.
;
Fauser, B. C.
;
Mol, B. W.
;
Broekmans, F. J. M.
.
HUMAN REPRODUCTION UPDATE,
2011, 17 (01)
:46-54

Broer, S. L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands

Dolleman, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands

论文数: 引用数:
h-index:
机构:

Fauser, B. C.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands

Mol, B. W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Obstet & Gynecol, NL-1105 AZ Amsterdam, Netherlands Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands

Broekmans, F. J. M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands Univ Med Ctr, Dept Reprod Med & Gynecol, NL-3508 GA Utrecht, Netherlands
[9]
The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count
[J].
Broer, Simtone L.
;
Mol, Ben Willem J.
;
Hendriks, Dave
;
Broekmans, Frank J. M.
.
FERTILITY AND STERILITY,
2009, 91 (03)
:705-714

Broer, Simtone L.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med, Div Obstet Neonatol & Gynecol, NL-3584 CX Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med, Div Obstet Neonatol & Gynecol, NL-3584 CX Utrecht, Netherlands

Mol, Ben Willem J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Amsterdam, Acad Med Ctr, Dept Obstet & Gynecol, NL-1105 AZ Amsterdam, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med, Div Obstet Neonatol & Gynecol, NL-3584 CX Utrecht, Netherlands

Hendriks, Dave
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med, Div Obstet Neonatol & Gynecol, NL-3584 CX Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med, Div Obstet Neonatol & Gynecol, NL-3584 CX Utrecht, Netherlands

Broekmans, Frank J. M.
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h-index: 0
机构:
Univ Med Ctr Utrecht, Dept Reprod Med, Div Obstet Neonatol & Gynecol, NL-3584 CX Utrecht, Netherlands Univ Med Ctr Utrecht, Dept Reprod Med, Div Obstet Neonatol & Gynecol, NL-3584 CX Utrecht, Netherlands
[10]
Antimullerian hormone serum levels: a putative marker for ovarian aging
[J].
de Vet, A
;
Laven, JSE
;
de Jong, FH
;
Themmen, APN
;
Fauser, BCJM
.
FERTILITY AND STERILITY,
2002, 77 (02)
:357-362

de Vet, A
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, Div Reprod Med, NL-3015 GD Rotterdam, Netherlands

Laven, JSE
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h-index: 0
机构: Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, Div Reprod Med, NL-3015 GD Rotterdam, Netherlands

de Jong, FH
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h-index: 0
机构: Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, Div Reprod Med, NL-3015 GD Rotterdam, Netherlands

Themmen, APN
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, Div Reprod Med, NL-3015 GD Rotterdam, Netherlands

Fauser, BCJM
论文数: 0 引用数: 0
h-index: 0
机构: Erasmus Univ, Med Ctr, Dept Obstet & Gynecol, Div Reprod Med, NL-3015 GD Rotterdam, Netherlands