A new cycloartanol sulfate from the green alga Tuemoya sp.: An inhibitor of VZV protease

被引：9

作者：

Patil, AD

Freyer, AJ

Killmer, L

Breen, A

Johnson, RK

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT BIOMOL DISCOVERY,RES & DEV,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT ANALYT SCI,RES & DEV,KING OF PRUSSIA,PA 19406

来源：

NATURAL PRODUCT LETTERS | 1997年 / 9卷 / 03期

关键词：

cycloartanol sulfate; green alga; VZV protease inhibitor;

D O I：

10.1080/10575639708048316

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

As part of a search for novel inhibitors of Herpes Zoster protease, the MeOH extract of the green alga Tuemoya sp. was shown to be active, Bioassay-guided fractionation of the extract yielded a previously reported cycloartane-3,28-disulfate-23-ol plus a novel compound that was identified as cycloart-24-en-23-one-28-sulfate-3-ol (1). These compounds demonstrated activity against both VZV and CMV protease in the 4-7 mu M range.

引用

页码：209 / 215

页数：7

共 6 条

[1] CONSTITUENTS OF TROPICAL MEDICINAL-PLANTS .54. CYCLOARTANES AND OTHER TERPENOIDS AND PHENYLPROPANOIDS FROM MONOCYCLANTHUS-VIGNEI [J].