Lipid peroxidation and renal cell carcinoma: Further supportive evidence and new mechanistic insights

被引：70

作者：

Gago-Dominguez, M ^{[1
]}

Castelao, JE ^{[1
]}

机构：

[1] Univ So Calif, Dept Prevent Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2006年 / 40卷 / 04期

关键词：

renal cell cancer; lipid peroxidation; apoptosis; VHL gene; hypoxia-inducible factors; oxidative stress; free radical;

D O I：

10.1016/j.freeradbiomed.2005.09.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have recently proposed lipid peroxidation as a unifying mechanistic pathway by which several seemingly unrelated risk/protective factors (obesity, hypertension, diabetes, smoking, oophorectomy/hysterectomy, parity, antioxidants) affect renal cell carcinoma development. In experimental studies, increased lipid peroxidation is a principal mechanistic pathway in renal carcinogenesis induced by different chemicals. In this communication, we provide additional lines of evidence that further support a role for lipid peroxidation on renal cell cancer development. (1) Lipid peroxidation may explain the role of other risk (analgesic use, pre-eclampsia) or protective (alcohol intake, oral contraceptives) factors for renal cell carcinoma. (2) Additional experimental evidence supports lipid peroxidation as an important mechanism in renal carcinogenesis, and (3) Existing evidence support a cross-talk between the lipid peroxidation pathway and other pathways that are relevant to renal carcinogenesis, Such as apoptosis, VHL, and possibly other pathways. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：721 / 733

页数：13

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