Phaeodactylum tricornutum: A Diatom Cell Factory

被引：155

作者：

Butler, Thomas ^{[1
]}

Kapoore, Rahul Vijay ^{[1
,2
]}

Vaidyanathan, Seetharaman ^{[1
]}

机构：

[1] Univ Sheffield, Dept Chem & Biol Engn, Sheffield S1 3JD, S Yorkshire, England

[2] Swansea Univ, Coll Sci, Dept Biosci, Swansea SA2 8PP, W Glam, Wales

来源：

TRENDS IN BIOTECHNOLOGY | 2020年 / 38卷 / 06期

基金：

英国生物技术与生命科学研究理事会; 英国工程与自然科学研究理事会;

关键词：

EICOSAPENTAENOIC ACID PRODUCTION; MULTIPLE METABOLIC NODES; MARINE MICROALGAE; INTERMEDIATE METABOLISM; FUCOXANTHIN PRODUCTION; LIPID-ACCUMULATION; EPA PRODUCTION; FATTY-ACIDS; NITROGEN; GENE;

D O I：

10.1016/j.tibtech.2019.12.023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A switch from a petroleum-based to a biobased economy requires the capacity to produce both high-value low-volume and low-value high-volume products. Recent evidence supports the development of microalgae-based microbial cell factories with the objective of establishing environmentally sustainable manufacturing solutions. Diatoms display rich diversity and potential in this regard. We focus on Phaeodactylum tricornutum, a pennate diatom that is commonly found in marine ecosystems, and discuss recent trends in developing the diatom chassis for the production of a suite of natural and genetically engineered products. Both upstream and downstream developments are reviewed for the commercial development of P. tricornutum as a cell factory for a spectrum of marketable products.

引用

页码：606 / 622

页数：17

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