General and Selective Copper-Catalyzed Reduction of Tertiary and Secondary Phosphine Oxides: Convenient Synthesis of Phosphines

被引：166

作者：

Li, Yuehui ^{[1
]}

Das, Shoubhik ^{[1
]}

Zhou, Shaolin ^{[1
]}

Junge, Kathrin ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 23期

关键词：

HIGHLY EFFICIENT; ENANTIOSELECTIVE HYDROGENATION; ASYMMETRIC HYDROPHOSPHINATION; STEREOSPECIFIC DEOXYGENATION; SELF-ENCAPSULATION; FUNCTIONAL-GROUP; REDUCING AGENT; LIGANDS; ARYL; SYSTEM;

D O I：

10.1021/ja301764m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel catalytic reductions of tertiary and secondary phosphine oxides to phosphines have been developed. Using tetramethyldisiloxane (TMDS) as a mild reducing agent in the presence of copper complexes, PO bonds are selectively reduced in the presence of other reducible functional groups (FGs) such as ketones, esters, and olefins. Based on this transformation, an efficient one pot reduction/phosphination domino sequence allows for the synthesis of a variety of functionalized aromatic and aliphatic phosphines in good yields.

引用

页码：9727 / 9732

页数：6