Impact of Chromatin on HIV Replication

被引：19

作者：

Agosto, Luis M. ^{[1
]}

Gagne, Matthew ^{[2
]}

Henderson, Andrew J. ^{[1
,2
]}

机构：

[1] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

[2] Boston Univ, Grad Program Microbiol, Sch Med, Boston, MA 02118 USA

来源：

GENES | 2015年 / 6卷 / 04期

关键词：

HIV; chromatin; integration; transcription; latency; HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; HISTONE DEACETYLASE INHIBITOR; LONG TERMINAL REPEAT; NF-KAPPA-B; ACTIVE ANTIRETROVIRAL THERAPY; BET BROMODOMAIN INHIBITION; INTEGRASE-BINDING DOMAIN; PML NUCLEAR-BODIES; RNA-POLYMERASE-II;

D O I：

10.3390/genes6040957

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromatin influences Human Immunodeficiency Virus (HIV) integration and replication. This review highlights critical host factors that influence chromatin structure and organization and that also impact HIV integration, transcriptional regulation and latency. Furthermore, recent attempts to target chromatin associated factors to reduce the HIV proviral load are discussed.

引用

页码：957 / 976

页数：20

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