Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma A case report

被引:9
作者
Guo, Linjie [1 ]
Wen, Zhonghui [1 ]
Su, Xueying [2 ]
Xiao, Shuyuan [3 ]
Wang, Yufang [1 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Gastroenterol, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Hosp, Dept Pathol, Chengdu, Sichuan, Peoples R China
[3] Univ Chicago, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA
基金
中国国家自然科学基金;
关键词
diffuse large B-cell lymphoma; indolent T-cell lymphoproliferative disease; intestinal obstruction; intestine perforation;
D O I
10.1097/MD.0000000000015323
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Rationale: Indolent T-cell lymphoproliferative disease (T-LPD) of gastrointestinal tract is a rare recently described disease that seldom progresses. We report a case of T-LPD with synchronous diffuse large B-cell lymphoma (DLBCL) that cause aggravation of disease. Patient concerns: A 46-year-old Chinese male presented with intermittent paraumbilical colic pain, bloating, and occasional diarrhea for 10 years. His condition aggravated with partial bowel obstruction recently. The patient was diagnosed as T-LPD initially based on histological result and T-cell receptor-gamma clonal gene rearrangement test. The patient was followed without chemotherapy. His condition stabilized for 1 year and then deteriorated with small intestine perforation. Diagnosis: The patient was diagnosed as indolent T-LPD and DLBCL finally. Interventions: The patient had surgery for intestine perforation and received chemotherapy for DLBCL and T-LPD afterward. Outcomes: At 6 months follow-up, the patient continued to have resolution of his symptoms. Lessons: Early detection of high-grade transformation of T-LPD or the coexistence of aggressive lymphoma is essential for the patient. DLBCL may coexist in the indolent course of T-LPD. The diagnosis of T-LPD should be made cautiously in case with progressing symptoms such as intestinal obstruction.
引用
收藏
页数:5
相关论文
共 11 条
[1]   Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease [J].
Brimnes, J ;
Allez, M ;
Dotan, I ;
Shao, L ;
Nakazawa, A ;
Mayer, L .
JOURNAL OF IMMUNOLOGY, 2005, 174 (09) :5814-5822
[2]   The clinicopathological features of extensive small intestinal CD4 T cell infiltration [J].
Carbonnel, F ;
d'Almagne, H ;
Lavergne, A ;
Matuchansky, C ;
Brouet, JC ;
Sigaux, F ;
Beaugerie, L ;
Nemeth, J ;
Coffin, B ;
Cosnes, J ;
Gendre, JP ;
Rambaud, JC .
GUT, 1999, 45 (05) :662-667
[3]   Diffuse Large B-cell Lymphoma in the elderly: standard treatment and new perspectives [J].
Chiappella, Annalisa ;
Castellino, Alessia ;
Nicolosi, Maura ;
Santambrogio, Elisa ;
Vitolo, Umberto .
EXPERT REVIEW OF HEMATOLOGY, 2017, 10 (04) :289-297
[4]   Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells [J].
Gattazzo, Cristina ;
Teramo, Antonella ;
Passeri, Francesca ;
De March, Elena ;
Carraro, Samuela ;
Trimarco, Valentina ;
Frezzato, Federica ;
Berno, Tamara ;
Barila, Gregorio ;
Martini, Veronica ;
Piazza, Francesco ;
Trentin, Livio ;
Facco, Monica ;
Semenzato, Gianpietro ;
Zambello, Renato .
HAEMATOLOGICA, 2014, 99 (12) :1826-1833
[5]   Indolent peripheral T-cell lymphoma involving the gastrointestinal tract [J].
Leventaki, Vasiliki ;
Manning, John T., Jr. ;
Luthra, Rajayalakshmi ;
Mehta, Pramod ;
Oki, Yasuhiro ;
Romaguera, Jorge E. ;
Medeiros, L. Jeffrey ;
Vega, Francisco .
HUMAN PATHOLOGY, 2014, 45 (02) :421-426
[6]   Indolent Small Intestinal CD4+T-cell Lymphoma Is a Distinct Entity with Unique Biologic and Clinical Features [J].
Margolskee, Elizabeth ;
Jobanputra, Vaidehi ;
Lewis, Suzanne K. ;
Alobeid, Bachir ;
Green, Peter H. R. ;
Bhagat, Govind .
PLOS ONE, 2013, 8 (07)
[7]   Indolent T-cell lymphoproliferative disease of the gastrointestinal tract [J].
Perry, Anamarija M. ;
Warnke, Roger A. ;
Hu, Qinglong ;
Gaulard, Philippe ;
Copie-Bergman, Christiane ;
Alkan, Serhan ;
Wang, Huan-You ;
Cheng, Jason X. ;
Bacon, Chris M. ;
Delabie, Jan ;
Ranheim, Erik ;
Kucuk, Can ;
Hu, XiaoZhou ;
Weisenburger, Dennis D. ;
Jaffe, Elaine S. ;
Chan, Wing C. .
BLOOD, 2013, 122 (22) :3599-3606
[8]   Tumor Necrosis Factor Receptor 2 Restricts the Pathogenicity of CD8+ T Cells in Mice With Colitis [J].
Punit, Shivesh ;
Dube, Philip E. ;
Liu, Cambrian Y. ;
Girish, Nandini ;
Washington, M. Kay ;
Polk, D. Brent .
GASTROENTEROLOGY, 2015, 149 (04) :993-U716
[9]   Indolent T-cell lymphoproliferative disease of the gastrointestinal tract in a renal transplant patient: diagnostic pitfalls and clinical challenges [J].
Soon, Gwyneth ;
Wang, Shi .
PATHOLOGY, 2017, 49 (05) :547-550
[10]   The 2016 revision of the World Health Organization classification of lymphoid neoplasms [J].
Swerdlow, Steven H. ;
Campo, Elias ;
Pileri, Stefano A. ;
Harris, Nancy Lee ;
Stein, Harald ;
Siebert, Reiner ;
Advani, Ranjana ;
Ghielmini, Michele ;
Salles, Gilles A. ;
Zelenetz, Andrew D. ;
Jaffe, Elaine S. .
BLOOD, 2016, 127 (20) :2375-2390