Copper-catalyzed thiolation of terminal aromatic alkynes to access alkynyl disulfides

被引：9
作者：
Li, Junhao [1 ]
Li, Ming [1 ]
Duan, Xuelun [1 ]
Song, Wangze [1 ,2 ]
机构：
[1] Dalian Univ Technol, Sch Chem Engn, Dept Pharmaceut Sci, State Key Lab Fine Chem, Dalian 116024, Peoples R China
[2] Zhongli Sci & Technol Grp Co Ltd, Changshu 215542, Jiangsu, Peoples R China
来源：
TETRAHEDRON LETTERS | 2020年 / 61卷 / 34期
基金：
中国国家自然科学基金;
关键词：
Alkynyl disulfides; Disulfur transfer; Thiolation; Copper-catalyzed; Steric hindrance; UNSYMMETRICAL DISULFANES; 1-ALKYNYL DISULFIDES; CYCLOADDITION; EFFICIENT; THIOLS; MILD;
D O I：
10.1016/j.tetlet.2020.152256
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed thiolation of terminal aromatic alkynes by disulfur transfer to access alkynyl disulfides was developed. Different types of products were afforded due to the steric hindrance of dithiolsulfonates. Some important compounds, such as fully substituted triazoles and pyrene-gemcitabine conjugate were prepared by this new approach. (C) 2020 Elsevier Ltd. All rights reserved.
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页数：4
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