Chemical constituents of Calophyllum brasiliensis:: Structure elucidation of seven new xanthones and their cancer chemopreventive activity

被引：77
作者：
Ito, C
Itoigawa, M [2 ]
Mishina, Y
Cechinel, V
Mukainaka, T
Tokuda, H
Nishino, H
Furukawa, H
机构：
[1] Meijo Univ, Fac Pharm, Nagoya, Aichi 4688503, Japan
[2] Tokai Gakuen Univ, Aichi 4700207, Japan
[3] UNIVALI, CCS, NIQFAR, BR-88302202 Itajai, SC, Brazil
[4] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyou Ku, Kyoto 6020841, Japan
来源：
JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 03期
关键词：
D O I：
10.1021/np010398s
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The first study of chemical constituents of the stem bark of Calophyllum brasilienses collected in Brazil has led to the isolation and identification of seven new xanthones named brasixanthones A (1), B (4), C (5), D (6), E (2), F (3), and G (10), together with 10 known xanthones. Among the xanthones isolated in this study, 4, 5, 6, and 11 were found to exhibit significant inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate induced Epstein-Barr virus early antigen activation in Raji cells.
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页码：267 / 272
页数：6
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