Deregulated systemic IL-10/IL-12 balance in advanced and poor prognosis paediatric soft tissue sarcomas

被引：7
作者：
Bien, Ewa [1 ]
Krawczyk, Malgorzata [1 ]
Izycka-Swieszewska, Ewa [2 ]
Trzonkowski, Piotr [3 ]
Kazanowska, Bernarda [4 ]
Adamkiewicz-Drozynska, Elzbieta [1 ]
Balcerska, Anna [1 ]
机构：
[1] Med Univ Gdansk, Dept Paediat Haematol Oncol & Endocrinol, PL-80211 Gdansk, Poland
[2] Med Univ Gdansk, Lab Gen Pathol & Neuropathol, PL-80211 Gdansk, Poland
[3] Med Univ Gdansk, Dept Clin Immunopathol & Transplantol, PL-80211 Gdansk, Poland
[4] Med Univ Wroclaw, Dept Paediat Oncol Haematol & Bone Marrow Transpl, Wroclaw, Poland
来源：
BIOMARKERS | 2013年 / 18卷 / 03期
关键词：
Children; interleukin; 10; 12; prognostic factors; soft tissue sarcomas; Th1/Th2; balance; ADVANCED COLORECTAL-CANCER; CYTOKINE SERUM LEVELS; DENDRITIC CELLS; GROWTH-FACTOR; TUMOR MICROENVIRONMENT; INTERLEUKIN-18; LEVELS; DISEASE PROGRESSION; ANTITUMOR IMMUNITY; IL-10; EXPRESSION; PLASMA-LEVELS;
D O I：
10.3109/1354750X.2013.764351
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Context: The roles of interleukin 10 (IL-10) and IL-12 in regulation of cancer growth and Th1/Th2 immune responses towards cancer are unclear. Objective: To establish the prognostic significance of serum IL-10 and IL-12 in paediatric soft tissue sarcomas (STS). Materials and methods: ELISA determinations of cytokines were performed as pre-treatment in 59 children with STS and 30 healthy controls. Results: Elevated IL-10 and decreased IL-12 serum levels correlated with advanced disease, poor response to chemotherapy and poor outcome. IL-10 >= 9.5 pg/ml, IL-12 <= 65 pg/ml and lymph nodes involvement independently predicted poor overall survival (OS) in multivariate Cox analysis. Conclusion: Serum IL-10/IL-12 balance determination may facilitate to assess risk groups and prognosis in childhood STS.
引用
收藏
页码：204 / 215
页数：12
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