Triterpenes and steroids from the leaves of Aglaia exima (Meliaceae)

被引：33

作者：

Awang, Khalijah ^{[1
]}

Loong, Xe-Min ^{[1
]}

Leong, Kok Hoong ^{[2
]}

Supratman, Unang ^{[3
]}

Litaudon, Marc ^{[4
]}

Mukhtar, Mat Ropi ^{[1
]}

Mohamad, Khalit ^{[2
]}

机构：

[1] Univ Malaya, Dept Chem, Kuala Lumpur 50603, Malaysia

[2] Univ Malaya, Dept Pharm, Kuala Lumpur 50603, Malaysia

[3] Padjadjaran State Univ, Dept Chem, Fac Math & Nat Sci, Jatinangor 45363, Indonesia

[4] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, Gif Sur Yvette, France

来源：

FITOTERAPIA | 2012年 / 83卷 / 08期

关键词：

Aglaia exima; Meliaceae; Cycloartane; Cytotoxicity; Steroids 24(E)-cycloart-24-ene-26-ol-3-one; CONSTITUENTS; DAMMARANE; BARK;

D O I：

10.1016/j.fitote.2012.10.004

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A study on the leaves of Aglaia exima led to the isolation of one new and seven known compounds: six triterpenoids and two steroids. Their structures were elucidated and analyzed mainly by using spectroscopic methods: 1D and 2D NMR, mass spectrometry, UV spectrometry and X-ray. All the triterpenoids and steroids were measured in vitro for their cytotoxic activities against eight cancer cell lines; lung (A549), prostate (DU-145), skin (SK-MEL-5), pancreatic (BxPC-3), liver (Hep G2), colon (HT-29), breast (MCF-7) and (MDA-MB-231). The new cycloartane triterpenoid, 24(E)-cycloart-24-ene-26-ol-3-one 1, showed potent cytotoxic activity against colon (HT-29) cancer cell line (IC50 11.5 mu M). (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1391 / 1395

页数：5

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