The effects of glucocorticoids on depressive and anxiety-like behaviors, mineralocorticoid receptor-dependent cell proliferation regulates anxiety-like behaviors

被引：16

作者：

Chen, Jiao ^{[1
,2
,3
]}

Wang, Zhen-zhen ^{[1
,2
,3
]}

Zhang, Shuai ^{[1
,2
,3
]}

Chu, Shi-feng ^{[1
,2
,3
,4
]}

Mou, Zheng ^{[1
,2
,3
]}

Chen, Nai-hong ^{[1
,2
,3
,4
,5
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

[4] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China

[5] Guangzhou Univ Chinese Med, Guangzhou 510000, Guangdong, Peoples R China

来源：

BEHAVIOURAL BRAIN RESEARCH | 2019年 / 362卷

基金：

中国博士后科学基金; 北京市自然科学基金; 高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

Depression; Anxiety; Cell proliferation; Serotonin; Glucocorticoids; Mineralocorticoid receptor; ADULT HIPPOCAMPAL NEUROGENESIS; DOSE CORTICOSTERONE; ECONOMIC BURDEN; STRESS; SEROTONIN; EXPRESSION; DISORDERS; RESPONSES; STEROIDS; AMYGDALA;

D O I：

10.1016/j.bbr.2019.01.026

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Glucocorticoids are vital stress response hormones and facilitate stress coping. However, sustained glucocorticoid exposure is associated with negative effects on brain. The precise role of glucocorticoids in depression and anxiety remains unclear. In the present study, we found that rats exposed to chronic unpredictable stress (CUS) showed anxiety-like behavior but not depressive-like behavior in the absence of glucocorticoid production. It was interesting to find that the level of serotonin (5-HT) and the expression of tryptophan hydroxylase-2 (TPH2) were decreased after CUS in the hippocampus in sham rats, while adrenalectomy (ADX) prevented such decreases. In addition, the neurogenesis in hippocampus decreased in both sham and ADX rats after stress exposure. Furthermore, inhibition of mineralocorticoid receptor (MR) with spironolactone induced anxiety like behavior in sham rats but not ADX rats. The proliferation of cells was blocked by spironolactone. In conclusion, our results indicate that MR-dependent neurogenesis was closely related with anxiety-like behavior.

引用

页码：288 / 298

页数：11

共 52 条

[1] Chronic cold in adrenalectomized, corticosterone (B)-treated rats: Facilitated corticotropin responses to acute restraint emerge as B increases [J].