Assessment of Corneal Biomechanical Properties with Inflation Test Using Optical Coherence Tomography

被引:18
作者
Wang, Like [1 ]
Tian, Lei [2 ,3 ,4 ]
Huang, Yanping [1 ,5 ]
Huang, Yifei [6 ]
Zheng, Yongping [1 ]
机构
[1] Hong Kong Polytech Univ, Dept Biomed Engn, Fac Engn, Kowloon, Hong Kong, Peoples R China
[2] Capital Med Univ, Beijing Inst Ophthalmol, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China
[3] Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China
[4] Natl Engn Res Ctr Ophthal, Beijing 100730, Peoples R China
[5] Foshan Univ, Sch Phys & Optoelect Engn, Foshan 528000, Peoples R China
[6] Chinese Peoples Liberat Army Gen Hosp, Dept Ophthalmol, Beijing 100853, Peoples R China
基金
中国国家自然科学基金; 北京市自然科学基金;
关键词
Deformation; Elasticity; Imaging; Stiffness; Viscoelasticity; Young's modulus; IN-VIVO; DEFORMATION; POSTERIOR; BEHAVIOR; MODULUS; ELASTICITY;
D O I
10.1007/s10439-017-1973-7
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Biomechanical properties are important for the cornea to maintain its normal shape and function. There is still a need to develop better methods for accurate measurement of corneal mechanical properties. In this study, we propose to introduce the optical coherence tomography (OCT) in inflation test for the imaging of corneal deformation in order to measure its biomechanical properties. Ten cornea-mimicking silicone phantoms with different stiffness and five fresh porcine corneas were tested using the proposed method. Intra-ocular pressure was changed from 10 to 90 mmHg using two different loading rates to observe the pressure-apex displacement relationship and calculate the apparent stiffness of the corneas. Stiffness of the corneal phantoms obtained by the inflation test ranged from 0.2 to 1 MPa, which was highly consistent with the results from the mechanical tensile test (y = 0.70x, p < 0.001). The porcine corneas showed highly viscoelastic behavior with obvious hysteresis in inflation. The apparent stiffness of the porcine corneas was 0.63 +/- 0.07 and 1.05 +/- 0.08 MPa with loading rates of 3.3 and 33 mmHg/min, respectively. Mapping of corneal surface displacement was also generated for both the phantom and porcine corneas. This study showed that it is feasible to incorporate the high resolution OCT imaging in inflation test to measure the biomechanical properties of the cornea.
引用
收藏
页码:247 / 256
页数:10
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