Increased numbers of gastric-infiltrating mast cells and regulatory T cells are associated with tumor stage in gastric adenocarcinoma patients

被引：18

作者：

Zhao, Yibin ^{[1
]}

Wu, Ke ^{[1
]}

Cai, Kailin ^{[1
]}

Zhai, Ronglin ^{[1
]}

Tao, Kaixiong ^{[1
]}

Wang, Guobin ^{[1
]}

Wang, Jiliang ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Dept Gastrointestinal Surg & Minimal Invas Surg, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

来源：

ONCOLOGY LETTERS | 2012年 / 4卷 / 04期

关键词：

gastric cancer; mast cells; regulatory T cells; TNM stage; coexpression; ESOPHAGEAL CANCERS; POOR-PROGNOSIS; ANGIOGENESIS; CARCINOMA; FOXP3; MICROENVIRONMENT; PROLIFERATION; PROGRESSION; STATISTICS; TOLERANCE;

D O I：

10.3892/ol.2012.830

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mast cells (MCs) and regulatory T cells (Tregs) are the important components of the inflammatory infiltrating leukocytes in most malignant tumors. Our study was designed to investigate the infiltrating correlation between MCs and Tregs and clarify their prognostic significance in gastric cancer (GC). A total of 60 fresh GC tissues were collected and tumor-infiltrating leukocytes were isolated by gradient centrifugation. Tryptase and Foxp3 were used as markers for MCs and Tregs, respectively. The expression of tryptase and Foxp3 was determined in tumor-infiltrating leukocytes using flow cytometry. The expression of tryptase and Foxp3 were positively correlated. The increased infiltration of MCs correlated significantly with advanced stage of GC. The infiltration of MCs into the tumor may increase the number of Tregs. Tryptase is a promising marker to stratify GC patients into different risk groups.

引用

页码：755 / 758

页数：4

共 36 条

[1] Tumour angiogenesis and mast cell density in the prognostic assessment of colorectal carcinomas [J].