Right ventricular systolic function for risk stratification in patients with stable left ventricular systolic dysfunction: comparison of radionuclide angiography to echoDoppler parameters
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de Groote, Pascal
[1
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Fertin, Marie
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Ctr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Univ Lille 2, Fac Med Lille, Lille, France
Univ Lille 2, Inst Pasteur Lille, INSERM, U744, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Fertin, Marie
[1
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,3
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Goeminne, Celine
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Ctr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Goeminne, Celine
[1
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Petyt, Gregory
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Univ Lille 2, Fac Med Lille, Lille, France
Ctr Hosp Reg & Univ Lille, Serv Med Nucl Pole Imagerie & Explorat Fonct, F-59037 Lille, FranceCtr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Petyt, Gregory
[2
,4
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Peyrot, Sandrine
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Ctr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Peyrot, Sandrine
[1
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Foucher-Hossein, Claude
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Univ Lille 2, Fac Med Lille, Lille, France
Ctr Hosp Reg & Univ Lille, Serv Med Nucl Pole Imagerie & Explorat Fonct, F-59037 Lille, FranceCtr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Foucher-Hossein, Claude
[2
,4
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Mouquet, Frederic
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Ctr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Mouquet, Frederic
[1
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Bauters, Christophe
[1
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Lamblin, Nicolas
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Ctr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Univ Lille 2, Inst Pasteur Lille, INSERM, U744, Lille, FranceCtr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
Lamblin, Nicolas
[1
,3
]
机构:
[1] Ctr Hosp Reg & Univ Lille, Hop Cardiol, Serv Cardiol Pole Cardiovasc & Pulm, Lille, France
[2] Univ Lille 2, Fac Med Lille, Lille, France
[3] Univ Lille 2, Inst Pasteur Lille, INSERM, U744, Lille, France
[4] Ctr Hosp Reg & Univ Lille, Serv Med Nucl Pole Imagerie & Explorat Fonct, F-59037 Lille, France
Aims Previous studies have demonstrated that the radionuclide right ventricular (RV) ejection fraction (RVEF), tricuspid annular plane systolic excursion (TAPSE), and tissue Doppler peak systolic tricuspid annular velocity (STr) were independent predictors of cardiac survival in stable patients with left ventricular systolic dysfunction (LVSD). No study has compared the prognostic value of these three RV parameters. The aim of this study was to compare the prognostic value of RVEF, TAPSE, and STr in a large group of patients with LVSD. Methods and results We analysed 527 consecutive patients who underwent an extensive prognostic evaluation (clinical data, biological data, radionuclide angiography, echoDopplercardiography, cardiopulmonary exercise test). Tricuspid annular plane systolic excursion and STr were weakly correlated with RVEF (r = 0.20). During a follow-up period of 1268 days (802-1830), there were 121 cardiovascular deaths. Best cut-off values were 37, 9.7 cm/s, and 18.5 mm for RVEF, STr, and TAPSE, respectively. Right ventricular ejection fraction was a powerful independent predictor of cardiac survival [relative risk (RR): 2.05 (1.29-3.26), P = 0.002]. Peak systolic tricuspid annular velocity added a modest prognostic information [RR: 1.56 (1.02-2.39), P = 0.04]. However, the combination of STr with RVEF was the most powerful predictor of cardiovascular death. Tricuspid annular plane systolic excursion was not an independent predictor of cardiac survival. Conclusions Right ventricular systolic function remains a powerful independent predictor of the clinical outcome. Even in the context of a complete echocardiographic assessment, radionuclide RVEF continues to be the most powerful RV systolic parameter for cardiac survival prediction. However, the determination of STr, in addition to RVEF, could improve risk stratification.
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Boston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USABoston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USA
Pencina, Michael J.
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D'Agostino, Ralph B., Sr.
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Boston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USABoston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USA
D'Agostino, Ralph B., Sr.
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D'Agostino, Ralph B., Jr.
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Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USABoston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USA
D'Agostino, Ralph B., Jr.
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Vasan, Ramachandran S.
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Boston Univ, Sch Med, Framingham Heart Study, Framingham, MA 01702 USABoston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USA
机构:
Boston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USABoston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USA
Pencina, Michael J.
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D'Agostino, Ralph B., Sr.
论文数: 0引用数: 0
h-index: 0
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Boston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USABoston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USA
D'Agostino, Ralph B., Sr.
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D'Agostino, Ralph B., Jr.
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机构:
Wake Forest Univ, Bowman Gray Sch Med, Dept Biostat Sci, Winston Salem, NC 27157 USABoston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USA
D'Agostino, Ralph B., Jr.
;
Vasan, Ramachandran S.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Med, Framingham Heart Study, Framingham, MA 01702 USABoston Univ, Dept Math & Stat, Framingham Heart Study, Boston, MA 02215 USA