High Cholesterol at the Heart of Phagolysosomal Damage

被引：4

作者：

Lieberman, Andrew P. ^{[1
]}

Swanson, Joel A. ^{[2
]}

机构：

[1] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

来源：

CELL METABOLISM | 2018年 / 27卷 / 03期

关键词：

NALP3; INFLAMMASOME; CRYSTALS; ACTIVATE;

D O I：

10.1016/j.cmet.2018.02.015

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Phagolysosome membrane rupture can trigger a maladaptive immune response that promotes tissue damage. In Science, Cantuti-Castelvetri et al. (2018) report that cholesterol-rich myelin debris overwhelms reverse cholesterol transport in aged phagocytes, leading to cholesterol crystal formation, damaged phagolysosomes, and limited tissue repair.

引用

页码：487 / 488

页数：2

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