SYNTHESIS OF AMINOMETHYL DERIVATIVES OF SOPHORICOSIDE

被引:4
作者
Bondarenko, S. P. [1 ]
Frasinyuk, M. S. [2 ]
Khilya, V. P. [3 ]
机构
[1] Natl Univ Food Technol, UA-01601 Kiev, Ukraine
[2] Natl Acad Sci Ukraine, Inst Bioorgan Chem & Petrochem, UA-02094 Kiev, Ukraine
[3] Taras Shevchenko Kiev Natl Univ, UA-01033 Kiev, Ukraine
关键词
isoflavone; sophoricoside; electrophilic substitution; aminomethylation; aminal; NERVOUS SYSTEM STIMULANTS; SOPHORA-JAPONICA; FLAVONOIDS; INHIBITION; ANALOGS;
D O I
10.1007/s10600-012-0151-2
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Aminomethylation of the natural isoflavonoid sophoricoside (genistein-4-O-beta-D-glucoside) was studied. It was shown that the most convenient method for performing the aminomethylation was the use of aminals. 6,8-bis-Substituted derivatives of sophoricoside were synthesized.
引用
收藏
页码:26 / 29
页数:4
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