Electrospinning Multilayered Scaffolds Loaded with Melatonin and Fe3O4 Magnetic Nanoparticles for Peripheral Nerve Regeneration

被引：108

作者：

Chen, Xuan ^{[1
,2
]}

Ge, Xuemei ^{[3
]}

Qian, Yun ^{[4
]}

Tang, Haozheng ^{[5
]}

Song, Jialin ^{[4
]}

Qu, Xinhua ^{[5
]}

Yue, Bing ^{[5
]}

Yuan, Wei-En ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Engn Res Ctr Cell & Therapeut Antibody, Minist Educ, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[3] Nanjing Forestry Univ, Coll Light Ind Sci & Engn, Dept Food Sci & Technol, Nanjing 210037, Peoples R China

[4] Shanghai Jiao Tong Univ, Dept Orthoped, Peoples Hosp 6, Shanghai 200233, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Renji Hosp, Dept Bone & Joint Surg,Dept Orthoped, 145 Shandong Middle Rd, Shanghai 200001, Peoples R China

来源：

ADVANCED FUNCTIONAL MATERIALS | 2020年 / 30卷 / 38期

基金：

中国国家自然科学基金;

关键词：

Fe(3)O(4)magnetic nanoparticles; melatonin; multilayered scaffold; nerve guidance conduit; peripheral nerve regeneration; SCIATIC-NERVE; FUNCTIONAL-EVALUATION; OXIDATIVE STRESS; SCHWANN-CELLS; INJURY; CONDUIT; RAT; REPAIR;

D O I：

10.1002/adfm.202004537

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peripheral nerve injury is a common clinical problem bringing heavy burden to patients, due to its high incidence and unsatisfactory treatment. Nerve guidance conduit (NGC) is a promising scaffold for peripheral nerve repair, and bioactive agents are applied for great functional recovery. Melatonin (MLT) and Fe(3)O(4)magnetic nanoparticles (Fe3O4-MNPs) are proven to inhibit oxidative stress, inflammation, and induce nerve regeneration. Herein, a multilayered composite NGC loaded with MLT and Fe3O4-MNPs is designed for sequential and sustainable drug release, creating an appropriate microenvironment for nerve regeneration. The composite scaffold shows sufficient mechanical strength and biocompatibility in vitro, and evidently promotes morphological, functional, and electrophysiological recovery of regenerated sciatic nerves in vivo. This work proves that the multilayered conduits show great prospect in the long-term nerve defects treatment due to easy manufacture and desired efficacy.

引用

页数：12

共 69 条

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