Childhood Tuberculosis and Malnutrition

被引：94
作者：
Jaganath, Devan [2 ,3 ]
Mupere, Ezekiel [1 ,3 ]
机构：
[1] Makerere Univ, Sch Med, Coll Hlth Sci, Dept Pediat & Child Hlth, Kampala, Uganda
[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA
[3] Case Western Reserve Univ, TB Res Unit TBRU, Cleveland, OH 44106 USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2012年 / 206卷 / 12期
基金：
美国国家卫生研究院;
关键词：
VITAMIN-D DEFICIENCY; NUTRITIONAL-STATUS; RESPIRATORY-INFECTION; IMMUNE-RESPONSE; CHILDREN; ZINC; SUPPLEMENTATION; INFANTS; UNDERNUTRITION; MACROPHAGES;
D O I：
10.1093/infdis/jis608
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Despite the burden of both malnutrition and tuberculosis in children worldwide, there are few studies on the mechanisms that underlie this relationship. From available research, it appears that malnutrition is a predictor of tuberculosis disease and is associated with worse outcomes. This is supported through several lines of evidence, including the role of vitamin D receptor genotypes, malnutrition's effects on immune development, respiratory infections among malnourished children, and limited work specifically on pediatric tuberculosis and malnutrition. Nutritional supplementation has yet to suggest significant benefits on the course of tuberculosis in children. There is a critical need for research on childhood tuberculosis, specifically on how nutritional status affects the risk and progression of tuberculosis and whether nutritional supplementation improves clinical outcomes or prevents disease.
引用
收藏
页码：1809 / 1815
页数：7
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