Repeated Administration of Amitriptyline Reduces Oxaliplatin-Induced Mechanical Allodynia in Rats

被引：16

作者：

Sada, Hikaru ^{[1
]}

Egashira, Nobuaki ^{[1
]}

Ushio, Soichiro ^{[1
]}

Kawashiri, Takehiro ^{[1
]}

Shirahama, Masafumi ^{[1
]}

Oishi, Ryozo ^{[1
]}

机构：

[1] Kyushu Univ Hosp, Dept Pharm, Higashi Ku, Fukuoka 8128582, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2012年 / 118卷 / 04期

关键词：

oxaliplatin; amitriptyline; peripheral neuropathy; TRICYCLIC ANTIDEPRESSANTS; NEUROPATHIC PAIN; RECEPTOR; GUIDELINES; EXPRESSION;

D O I：

10.1254/jphs.12006SC

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies in patients. Amitriptyline has widely been used in patients with painful neuropathy. In this study, we investigated the effect of amitriptyline on the oxaliplatin-induced neuropathy in rats. Repeated administration of amitriptyline (5 and 10 mg/kg, p.o., once a day) reduced the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia and reversed the oxaliplatin-induced increase in the expression of NR2B protein and mRNA in rat spinal cord. These results suggest that amitriptyline is useful for the treatment of oxaliplatin-induced neuropathy clinically.

引用

页码：547 / 551

页数：5

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