Palladium-Catalyzed Carbonylative Synthesis of N-Heterocycles from 1-Chloro-2-fluorobenzenes

被引：12

作者：

Yuan, Yang ^{[1
]}

Wu, Xiao-Feng ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 2019卷 / 11期

关键词：

N-heterocycles; Carbonylation; Aryl chlorides; Nucleophilic aromatic substitution; Palladium; INDOLOPYRIDOQUINAZOLINE ALKALOIDS; ARYL CHLORIDES; BOND-CLEAVAGE; C-H; QUINAZOLINONES; AMINOCARBONYLATION; QUINAZOLIN-4(3H)-ONES; FUNCTIONALIZATION; DERIVATIVES; CYCLIZATION;

D O I：

10.1002/ejoc.201900232

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient synthesis of pyrido-fused quinazolinones and dibenzoxazepinones by palladium-catalyzed annulation of commercially available substituted 1-chloro-2-fluorobenzenes and 2-aminopyridines or 2-aminophenols has been developed. The reaction involves carbonylation/aromatic nucleophilic substitution sequential in a one-pot manner.

引用

页码：2172 / 2175

页数：4

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