Proteomic Approaches to the Discovery of Cancer Biomarkers for Early Detection and Personalized Medicine

被引：45

作者：

Honda, Kazufumi ^{[1
]}

Ono, Masaya ^{[1
]}

Shitashige, Miki ^{[1
]}

Masuda, Mari ^{[1
]}

Kamita, Masahiro ^{[1
]}

Miura, Nami ^{[1
]}

Yamada, Tesshi ^{[1
]}

机构：

[1] Natl Canc Ctr, Res Inst, Dept Chemotherapy & Clin Res, Tokyo 1040045, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2013年 / 43卷 / 02期

关键词：

cancer biomarker; personalized medicine; early detection; proteomics; ANTIBODY-BASED PROTEOMICS; HUMAN PROTEIN ATLAS; CELL LUNG-CANCER; PANCREATIC-CANCER; LIQUID-CHROMATOGRAPHY; GEL-ELECTROPHORESIS; CLINICAL PROTEOMICS; IDENTIFICATION; MICROARRAYS; MICRODISSECTION;

D O I：

10.1093/jjco/hys200

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer biomarkers for the early detection of malignancies and selection of therapeutic strategies have been requested in the clinical field. Accurate and informative cancer biomarkers hold significant promise for improvements in the early detection of disease and in the selection of the most effective therapeutic strategies. Recently, significant progress in the comprehensive analysis of the human genome, epigenome, transcriptome, proteome and metabolome has led to revolutionary changes in the discovery of cancer biomarkers. The Human Proteome Organization has launched a global Human Proteome Project to map the entire human protein set. The Human Proteome Project research group has focused on three working proteomic pillarsumass spectrometry-based, antibody-based and knowledge-based proteomicsuand each of these technologies is advancing rapidly. In this review, we introduce the proteomic platforms that are currently being used for cancer biomarker discovery, and describe examples of novel cancer biomarkers that were identified with each proteomic technology.

引用

页码：103 / 109

页数：7

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