Evaluation of CD4+CD25+ T lymphocyte response time kinetics in patients with chronic Chagas disease after in vitro stimulation with recombinant Trypanosoma cruzi antigens

被引：2
作者：
de Moura Braz, Suellen Carvalho [1 ]
Barros de Lorena, Virginia Maria [1 ,2 ]
Melo, Adriene Siqueira [1 ]
Aureliano Melo Cavalcanti, Maria da Gloria [3 ]
Gomes, Yara de Miranda [1 ,2 ]
机构：
[1] Fundacao Oswaldo Cruz, Ctr Pesquisas Aggeu Magalhaes, Recife, PE, Brazil
[2] Fundacao Oswaldo Cruz, Programa Integrado Doenca Chagas, Rio De Janeiro, RJ, Brazil
[3] Univ Pernambuco, Prontosocorro Cardiol Pernambuco, Recife, PE, Brazil
来源：
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2013年 / 46卷 / 03期
关键词：
Chronic Chagas disease; Recombinant antigens; CD4(+)CD25(+) T lymphocytes; CELLS; ANTIBODIES; CRA;
D O I：
10.1590/0037-8682-1323-2013
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Introduction: CD4(+)CD25(+) T lymphocytes have been implicated in the regulation of host inflammatory response against Trypanosoma cruzi, and may be involved in the clinical course of the disease. Methods: Peripheral blood mononuclear cells from patients with chronic Chagas disease were cultured in the presence of T. cruzi recombinant antigens and assayed for lymphocytes at distinct time points. Results: It was possible to differentiate clinical forms of chronic Chagas disease at days 3 and 5 according to presence of CD4(+)CD25(+) T cells in cell cultures. Conclusions: Longer periods of cell culture proved to be potentially valuable for prospective evaluations of CD4(+)CD25(+) T lymphocytes in patients with chronic Chagas disease.
引用
收藏
页码：362 / 366
页数：5
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