TGF-β and osteoarthritis-the good and the bad

被引：54
|
作者：
Bush, Jason R. [1 ]
Beier, Frank [1 ]
机构：
[1] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada
来源：
NATURE MEDICINE | 2013年 / 19卷 / 06期
关键词：
OSTEOPHYTE FORMATION; ARTICULAR-CARTILAGE; BONE; DISEASE; DIFFERENTIATION;
D O I：
10.1038/nm.3228
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Blockage of transforming growth factor-β (TGF-β) signaling in subchondral bone after acute injury in rodents prevents aberrant bone remodeling and cartilage degeneration, suggesting that TGF-β signaling in bone may initiate osteoarthritis in some cases (pages 704–712).
引用
收藏
页码：667 / 669
页数：3
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