TGF-β and osteoarthritis-the good and the bad

被引：55

作者：

Bush, Jason R. ^{[1
]}

Beier, Frank ^{[1
]}

机构：

[1] Univ Western Ontario, Schulich Sch Med & Dent, Dept Physiol & Pharmacol, London, ON, Canada

来源：

NATURE MEDICINE | 2013年 / 19卷 / 06期

关键词：

OSTEOPHYTE FORMATION; ARTICULAR-CARTILAGE; BONE; DISEASE; DIFFERENTIATION;

D O I：

10.1038/nm.3228

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Blockage of transforming growth factor-β (TGF-β) signaling in subchondral bone after acute injury in rodents prevents aberrant bone remodeling and cartilage degeneration, suggesting that TGF-β signaling in bone may initiate osteoarthritis in some cases (pages 704–712).

引用

页码：667 / 669

页数：3

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