Lack of Evidence of the Role of APOA5 3'UTR Polymorphisms in Iranian Children and Adolescents with Metabolic Syndrome

被引:2
|
作者
Salehi, Samaneh [1 ]
Emadi-Baygi, Modjtaba [1 ,2 ]
Rezaei, Majdaddin [3 ,4 ]
Kelishadi, Roya [5 ]
Nikpour, Parvaneh [3 ,4 ,5 ]
机构
[1] Shahrekord Univ, Dept Genet, Fac Basic Sci, Shahrekord, Iran
[2] Shahrekord Univ, Res Inst Biotechnol, Shahrekord, Iran
[3] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Pediat Inherited Dis Res Ctr, Esfahan, Iran
[4] Isfahan Univ Med Sci, Dept Genet & Mol Biol, Fac Med, Esfahan, Iran
[5] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Esfahan, Iran
关键词
Apolipoprotein A-V; Haplotypes; Metabolic syndrome; miR-TS-SNP; CORONARY-ARTERY-DISEASE; MICRORNA TARGET SITES; APOLIPOPROTEIN A-V; LINKING POLYMORPHISMS; POLYMIRTS DATABASE; RISK; GENE; TRIGLYCERIDE; VARIANTS;
D O I
10.4093/dmj.2018.42.1.74
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Metabolic syndrome (MetS) is a complex and multifactorial disorder characterized by insulin resistance, dyslipidaemia, hyperglycemia, abdominal obesity, and elevated blood pressure. The apolipoprotein A5 (APOA5) gene variants have been reported to correlate with two major components of MetS, including low levels of high density lipoprotein cholesterol (HDL-C) and high levels of triglyceride. In the present study, we explored the associations between five single nucleotide polymorphisms (SNPs) of APOA5 gene and the MetS risk. Methods: In a case-control design, 120 Iranian children and adolescents with/without MetS were genotyped by polymerase chain reaction-sequencing for these SNPs. Then, we investigated the association of SNPs, individually or in haplotype constructs, with MetS risk. Results: The rs34089864 variant and H1 haplotype (harboring the two major alleles of rs619054 and rs34089864) were associated with HDL-C levels. However, there was no significant association between different haplotypes/individual SNPs and MetS risk. Conclusion: These results presented no association of APOA5 3'UTR SNPs with MetS. Further studies, including other polymorphisms, are required to investigate the involvement of APOA5 gene in the genetic susceptibility to MetS in the pediatric age group.
引用
收藏
页码:74 / 81
页数:8
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