Cross-Talk between Lung and Systemic Circulation during Carbon Nanotube Respiratory Exposure. Potential Biomarkers

被引：123

作者：

Erdely, Aaron ^{[1
]}

Hulderman, Tracy ^{[1
]}

Salmen, Rebecca ^{[1
]}

Liston, Angle ^{[1
]}

Zeidler-Erdely, Patti C. ^{[2
]}

Schwegler-Berry, Diane ^{[2
]}

Castranova, Vincent ^{[2
]}

Koyama, Shozo ^{[3
]}

Kim, Yoong-Ahm ^{[3
]}

Endo, Morinobu ^{[3
]}

Simeonova, Petia P. ^{[1
]}

机构：

[1] NIOSH, Toxicol & Mol Biol Branch, Hlth Effects Lab Div, Morgantown, WV 26505 USA

[2] NIOSH, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Morgantown, WV 26505 USA

[3] Shinshu Univ, Fac Engn, Nagano 3808553, Japan

来源：

NANO LETTERS | 2009年 / 9卷 / 01期

关键词：

PLASMINOGEN-ACTIVATOR INHIBITOR-1; LONG-TERM EXPOSURE; PULMONARY EXPOSURE; GENE-EXPRESSION; AIR-POLLUTION; INTRATRACHEAL INSTILLATION; MOUSE LUNG; INFLAMMATION; PARTICLES; DISEASE;

D O I：

10.1021/nl801828z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanotechnology is an emerging field that demands urgent development of adequate toxicology and risk assessment. The previous experimental data on carbon nanotube respiratory exposure strongly suggest the need for complex evaluation of potential toxicity. Our work demonstrates that after carbon nanotube deposition in the lung, acute local and systemic responses are activated and characterized by a blood gene and protein expression signature. The approach described here will foster the development of biomarkers for application in human screening of nanoparticle exposure.

引用

页码：36 / 43

页数：8

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