Action and function of Faecalibacterium prausnitzii in health and disease

被引：365

作者：

Ferreira-Halder, Carmen Verissima ^{[1
]}

de Sousa Faria, Alessandra Valeria ^{[1
]}

Andrade, Sheila Siqueira ^{[2
]}

机构：

[1] Univ Estadual Campinas, Dept Biochem & Tissue Biol, Sao Paulo, Brazil

[2] Plateinnove Biotechnol, 1131 Limeira Ave,RM 10, Sao Paulo, Brazil

来源：

BEST PRACTICE & RESEARCH CLINICAL GASTROENTEROLOGY | 2017年 / 31卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Faecalibacterium prausnitzii; Biology; Anti-inflammatory; Platelets function; BUTYRATE-PRODUCING BACTERIA; INFLAMMATORY-BOWEL-DISEASE; GUT MICROBIOTA; CROHNS-DISEASE; COLONIC MICROBIOTA; FECAL MICROBIOTA; PLATELETS; POLYPHENOLS; MODULATION; DIVERSITY;

D O I：

10.1016/j.bpg.2017.09.011

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Faecalibacterium prausnitzii, anaerobic bacteria, is one of the main components of gut microbiota and the most important butyrate-producing bacteria in the human colon. So far, this commensal bacterium has been considered as a bioindicator of human health, once when its population is altered (decreased), inflammatory processes are favored. Several reports in the literature highlighted that the amount of Faecalibacterium prausnitzii negatively correlates to the activity of inflammatory bowel disease and colorectal cancer. Therefore, counterbalancing dysbiosis using Faecalibacterium prausnitzii as a potential active component of probiotic formulations appears to be a promising therapeutic strategy for inflammatory bowel diseases and colorectal cancer. However, once this microbial is very sensitive to oxygen, the formulation development is a great challenge. In this review, we will focus our attention on Faecalibacterium prausnitzii biology, anti-inflammatory metabolites, modulators of this bacterium population and its impact on human health. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：643 / 648

页数：6

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