The antimalarial activity of indole alkaloids and hybrids

被引：19

作者：

Li, Jue-Ying ^{[1
]}

Sun, Xiao-Feng ^{[1
]}

Li, Jing-Jing ^{[1
]}

Yu, Fen ^{[1
]}

Zhang, Yi ^{[1
]}

Huang, Xiu-Juan ^{[1
]}

Jiang, Feng-Xia ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Cent Hosp Wuhan, Ultrasonog Dept, Wuhan 430074, Peoples R China

来源：

ARCHIV DER PHARMAZIE | 2020年 / 353卷 / 11期

关键词：

alkaloids; antimalarial; antiplasmodial; hybrid compounds; indole; IN-VIVO ANTIMALARIAL; ANTIPLASMODIAL ACTIVITY; STRYCHNOGUCINE-B; NATURAL-PRODUCTS; DERIVATIVES; VITRO; ANALOGS; BARK; MERIDIANIN; IDENTIFICATION;

D O I：

10.1002/ardp.202000131

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Malaria, caused by the genusPlasmodium, remains a global public health concern. It is estimated by the World Health Organization that over 40% of the world's population lives in areas at risk for malarial transmission, and around half a million people succumb to this infectious disease annually, which is related to the rapid spread of drug-resistant parasite strains. Indole derivatives, which possess broad-spectrum pharmacological properties, play a crucial role in the discovery of new drugs. Many indole derivatives exhibited potential in vitro and in vivo activity against both drug-sensitive and drug-resistant malaria, suggesting that the indole moiety is a useful template for the development of novel antimalarial agents. This review outlines the advances in indole alkaloids and hybrids with antimalarial potential in the recent decade.

引用

页数：11

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