Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering

被引：117
作者：
Alrifaiy, Ahmed [1 ,2 ]
Lindahl, Olof A. [1 ,2 ,3 ]
Ramser, Kerstin [1 ,2 ]
机构：
[1] Lulea Univ Technol, Dept Comp Sci Elect & Space Engn, SE-97187 Lulea, Sweden
[2] Lulea Univ Technol, Ctr Biomed Engn & Phys, CMTF, SE-97187 Lulea, Sweden
[3] Umea Univ, Dept Radiat Sci, SE-90187 Umea, Sweden
来源：
POLYMERS | 2012年 / 4卷 / 03期
关键词：
microfluidics; tissue engineering; biomedical engineering; polymers; biocompatibility; cell sorting; cell analysis; cell biology; ON-A-CHIP; TOTAL ANALYSIS SYSTEMS; MINIATURIZED TOTAL ANALYSIS; MAMMALIAN-CELL CULTURE; BREAST-CANCER CELLS; ENDOTHELIAL-CELLS; PERFUSION-CULTURE; OPTICAL TWEEZERS; FLOW-CYTOMETRY; CHAIN-REACTION;
D O I：
10.3390/polym4031349
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This paper reviews microfluidic technologies with emphasis on applications in the fields of pharmacy, biology, and tissue engineering. Design and fabrication of microfluidic systems are discussed with respect to specific biological concerns, such as biocompatibility and cell viability. Recent applications and developments on genetic analysis, cell culture, cell manipulation, biosensors, pathogen detection systems, diagnostic devices, high-throughput screening and biomaterial synthesis for tissue engineering are presented. The pros and cons of materials like polydimethylsiloxane (PDMS), polymethylmethacrylate (PMMA), polystyrene (PS), polycarbonate (PC), cyclic olefin copolymer (COC), glass, and silicon are discussed in terms of biocompatibility and fabrication aspects. Microfluidic devices are widely used in life sciences. Here, commercialization and research trends of microfluidics as new, easy to use, and cost-effective measurement tools at the cell/tissue level are critically reviewed.
引用
收藏
页码：1349 / 1398
页数：50
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