Protein linguistics - a grammar for modular protein assembly?

被引:54
作者
Gimona, M [1 ]
机构
[1] Ist Ric Farmacol Mario Negri, Consorzio Mario Negri Sud, Marie Curie Unit Actin Cytoskeleton Regulat, Dept Cell Biol & Oncol, I-66030 Santa Maria Imbaro, Italy
关键词
D O I
10.1038/nrm1785
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The correspondence between biology and linguistics at the level of sequence and lexical inventories, and of structure and syntax, has fuelled attempts to describe genome structure by the rules of formal linguistics. But how can we define protein linguistic rules? And how could compositional semantics improve our understanding of protein organization and functional plasticity?
引用
收藏
页码:68 / 73
页数:7
相关论文
共 48 条
[1]   Normalization of nomenclature for peptide motifs as ligands of modular protein domains [J].
Aasland, R ;
Abrams, C ;
Ampe, C ;
Ball, LJ ;
Bedford, MT ;
Cesareni, G ;
Gimona, M ;
Hurley, JH ;
Jarchau, T ;
Lehto, VP ;
Lemmon, MA ;
Linding, R ;
Mayer, BJ ;
Nagai, M ;
Sudol, M ;
Walter, U ;
Winder, SJ .
FEBS LETTERS, 2002, 513 (01) :141-144
[2]   Bcr: a negative regulator of the Bcr-Abi oncoprotein in leukemia [J].
Arlinghaus, RB .
ONCOGENE, 2002, 21 (56) :8560-8567
[3]  
Baker Mark., 2001, ATOMS LANGUAGE
[4]   Network biology:: Understanding the cell's functional organization [J].
Barabási, AL ;
Oltvai, ZN .
NATURE REVIEWS GENETICS, 2004, 5 (02) :101-U15
[5]   Evolution, language and analogy in functional genomics [J].
Benner, SA ;
Gaucher, EA .
TRENDS IN GENETICS, 2001, 17 (07) :414-418
[6]   Biosequence exegesis [J].
Boguski, MS .
SCIENCE, 1999, 286 (5439) :453-455
[7]   Molecular linguistics: Extracting information from gene and protein sequences [J].
Botstein, D ;
Cherry, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (11) :5506-5507
[8]   GENOME STRUCTURE DESCRIBED BY FORMAL LANGUAGES [J].
BRENDEL, V ;
BUSSE, HG .
NUCLEIC ACIDS RESEARCH, 1984, 12 (05) :2561-2568
[9]   LINGUISTICS OF NUCLEOTIDE-SEQUENCES - MORPHOLOGY AND COMPARISON OF VOCABULARIES [J].
BRENDEL, V ;
BECKMANN, JS ;
TRIFONOV, EN .
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1986, 4 (01) :11-21
[10]  
Cesareni G., 2004, Modular Protein Domains