Sensitivity of the human circadian system to short-wavelength (420-nm) light

被引:193
作者
Brainard, George C. [1 ]
Sliney, David [2 ]
Hanifin, John P. [1 ]
Glickman, Gena [1 ]
Byrne, Brenda [1 ]
Greeson, Jeffrey N. [1 ]
Jasser, Samar [1 ]
Gerner, Edward [1 ]
Rollag, Mark D. [1 ]
机构
[1] Thomas Jefferson Univ, Dept Neurol, Philadelphia, PA 19107 USA
[2] USA, Ctr Hlth Promot & Prevent Med, Laser Opt Radiat Program, Aberdeen Proving Ground, MD USA
关键词
melatonin; action spectrum; circadian; wavelength; light; pineal gland; neuroeodocrine; photoreception;
D O I
10.1177/0748730408323089
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The circadian and neurobehavioral effects of light are primarily mediated by a retinal ganglion cell photoreceptor in the mammalian eye containing the photopigment melanopsin. Nine action spectrum studies using rodents, monkeys, and humans for these responses indicate peak sensitivities in the blue region of the visible specturm ranging from 459 to 484 nm, with some disagreement in short-wavelength sensitivity of the spectrum. The aim of this work was to quantify the sensitivity of human volunteers to monochromatic 420-nm light for plasma melatonin suppression. Adult female (n = 14) and male (n = 12) subjects participated in 2 studies, each employing a within-subjects design. In a ftuence-response study, subjects (n = 8) were tested with 8 light irradiances at 420 nm ranging over a 4-log unit photon density range of 10(10) to 10(14) photons/cm(2)/sec and 1 dark control flight. In the other study subjects (n = 18) completed an experiment comparing melatonin suppression with equal photon doses (1.21. X 10(13) photons/cm(2)/sec) of 420 nm ans 460 nm monochromatic light and a dark exposure control night. The first study demonstrated a clear fluence-response relationship between 420-nm light and melatonin suppression (p < 0.001) with a half-saturation constant of 2.74 x 10(11) photons/cm(2)/sec. The second study showed that 460-nm light is significantly stronger than 420-nm light for suppressing melatonin (p < 0.04). Together, the results clarify the visible short-wavelenght sensitivity of the human melatonin suppression action spectrum. This basic physiological finding may be useful for optimizing lighting for therapeutic and other applications.
引用
收藏
页码:379 / 386
页数:8
相关论文
共 37 条
[1]  
American Conference of Governmental Industrial Hygienists, 2006, DOC THRESH LIM VAL B
[2]   Phototransduction by retinal ganglion cells that set the circadian clock [J].
Berson, DM ;
Dunn, FA ;
Takao, M .
SCIENCE, 2002, 295 (5557) :1070-1073
[3]   Photic regulation of melatonin in humans: Ocular and neural signal transduction [J].
Brainard, GC ;
Rollag, MD ;
Hanifin, JP .
JOURNAL OF BIOLOGICAL RHYTHMS, 1997, 12 (06) :537-546
[4]   Photons, clocks, and consciousness [J].
Brainard, GC ;
Hanifin, JP .
JOURNAL OF BIOLOGICAL RHYTHMS, 2005, 20 (04) :314-325
[5]  
Brainard GC, 2001, J NEUROSCI, V21, P6405
[6]   High sensitivity of human melatonin, alertness, thermoregulation, and heart rate to short wavelength light [J].
Cajochen, C ;
Münch, M ;
Kobialka, S ;
Kräuchi, K ;
Steiner, R ;
Oelhafen, P ;
Orgül, S ;
Wirz-Justice, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (03) :1311-1316
[7]  
*COMM INT ECL, 2002, PHOT SAF LAMPS LAMP
[8]  
*COMM INT ECL, 2006, OC LIGHT EFF HUM PHY
[9]  
*COMM INT ECL, 2006, P 2 CIE S LIGHT HLTH
[10]   Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN [J].
Dacey, DM ;
Liao, HW ;
Peterson, BB ;
Robinson, FR ;
Smith, VC ;
Pokorny, J ;
Yau, KW ;
Gamlin, PD .
NATURE, 2005, 433 (7027) :749-754